Photophysical Properties and Efficiency of Singlet Oxygen Formation by a pH-Sensitive Sensitizer Based on Meso-Tetrakis(4-N-Methylpyridyl)Porphyrin and Hydroxyapatite Nanoparticles

IF 0.8 4区化学 Q4 SPECTROSCOPY Journal of Applied Spectroscopy Pub Date : 2024-07-05 DOI:10.1007/s10812-024-01746-4

M. V. Parkhats, S. V. Lepeshkevich, A. V. Petkevich, M. V. Verameichyk, A. A. Rogachev, S. N. Terekhov, D. Tuncel, B. M. Dzhagarov

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Abstract

The photophysical properties and efficiency of photosensitized singlet oxygen formation by meso-tetrakis(4- N-methylpyridyl)porphyrin in a complex with hydroxyapatite nanoparticles were studied. At least three types of complexes characterized by different access of oxygen to porphyrin molecules were shown to form on the surface of the hydroxyapatite nanoparticles. Rotation of the pyridyl substituents of porphyrin in the complex with hydroxyapatite nanoparticles was found to be significantly hindered, while porphyrin molecules on the surface of the nanoparticles were in a less polar environment than in water. The quantum yield of photosensitized singlet oxygen formation was observed to decrease by at least nine times for porphyrin in the complex with hydroxyapatite nanoparticles. Porphyrin was released from hydroxyapatite nanoparticles and the efficiency of singlet oxygen formation increased although it did not reach the values characteristic for free porphyrin if the pH decreased to less than 5.0 (pH < 5.0).

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基于中-四（4-N-甲基吡啶基）卟啉和羟基磷灰石纳米颗粒的 pH 敏感敏化剂形成单线态氧的光物理特性和效率

研究了中四(4-N-甲基吡啶基)卟啉与羟基磷灰石纳米粒子复合物的光物理特性和光敏单线态氧形成的效率。结果表明，在羟基磷灰石纳米颗粒表面至少形成了三种类型的复合物，其特点是氧与卟啉分子的接触情况各不相同。研究发现，在与羟基磷灰石纳米粒子的复合物中，卟啉的吡啶基取代基旋转明显受阻，而纳米粒子表面的卟啉分子所处的极性环境比在水中要低。据观察，卟啉与羟基磷灰石纳米颗粒复合物形成光敏单线态氧的量子产率至少降低了 9 倍。卟啉从羟基磷灰石纳米颗粒中释放出来，单线态氧的形成效率也随之提高，但如果 pH 值降至 5.0 以下（pH 值为 5.0），卟啉的形成效率还达不到游离卟啉的特征值。

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来源期刊

Journal of Applied Spectroscopy SPECTROSCOPY-

CiteScore

1.30

自引率

14.30%

发文量

145

审稿时长

2.5 months

期刊介绍： Journal of Applied Spectroscopy reports on many key applications of spectroscopy in chemistry, physics, metallurgy, and biology. An increasing number of papers focus on the theory of lasers, as well as the tremendous potential for the practical applications of lasers in numerous fields and industries.