Mechanical and biocompatibility properties of UHMWPE–HNT composite for joint replacement applications

IF 1.9 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Bulletin of Materials Science Pub Date : 2024-07-04 DOI:10.1007/s12034-024-03274-5

Rania Hasan, Sarang Pande, Pravin Bhalerao

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Abstract

Ultrahigh molecular-weight polyethylene (UHMWPE)-based composites are extensively utilized as a bearing surface in joint replacements. In the present study, due to their unique and versatile attributes halloysite nanotubes (HNTs) were used as additives in different percentages 1, 3, 5, 7 and 10 wt% to enhance the properties of UHMWPE. The effects of the weight fraction of HNT on UHMWP were investigated in terms of hardness, abrasion strength, compression strength, bulk modulus, impact resistance and biocompatibility, and the specimen showed that only a small amount of HNT (1%) optimized all the mentioned properties by 26.8, 20.77, 174.7, 351.53, 11.35 and 95%, respectively. The percentage of 5% HNT achieved the optimal content, at which the composites experienced the maximum enhancement for compression, abrasion and hardness properties. In-vitro MTT assay of UHMWPE with 1, 3 and 5% HNT nanocomposites using MG-63 cells revealed high cell viability (94.307%) after 4 days of incubation in media at concentrations of 100, 50 and 25 µg ml^–1, indicating excellent biocompatibility. These results might lay a solid basis for load bearings used in orthopaedic applications of UHMWPE-based composites.

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用于关节置换的超高分子量聚乙烯-HNT 复合材料的机械和生物相容性能

基于超高分子量聚乙烯（UHMWPE）的复合材料在关节置换中被广泛用作承重面。在本研究中，由于霍洛石纳米管（HNT）具有独特的多功能属性，因此将其作为添加剂，以 1、3、5、7 和 10 wt% 的不同比例来增强超高分子量聚乙烯的性能。研究了 HNT 重量分数对超高分子量聚乙烯硬度、耐磨强度、压缩强度、体积模量、抗冲击性和生物相容性的影响，结果表明，仅少量 HNT（1%）就能优化所有上述性能，优化幅度分别为 26.8%、20.77%、174.7%、351.53%、11.35% 和 95%。5% 的 HNT 百分比达到了最佳含量，在此含量下，复合材料的压缩、磨损和硬度性能得到了最大程度的提高。使用 MG-63 细胞对含有 1%、3% 和 5% HNT 纳米复合材料的超高分子量聚乙烯进行体外 MTT 检测，结果显示，在 100、50 和 25 µg ml-1 浓度的培养基中培养 4 天后，细胞存活率很高（94.307%），这表明该复合材料具有良好的生物相容性。这些结果为超高分子量聚乙烯基复合材料在骨科应用中的负载轴承奠定了坚实的基础。

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来源期刊

Bulletin of Materials Science 工程技术-材料科学：综合

CiteScore

3.40

自引率

5.60%

发文量

209

审稿时长

11.5 months

期刊介绍： The Bulletin of Materials Science is a bi-monthly journal being published by the Indian Academy of Sciences in collaboration with the Materials Research Society of India and the Indian National Science Academy. The journal publishes original research articles, review articles and rapid communications in all areas of materials science. The journal also publishes from time to time important Conference Symposia/ Proceedings which are of interest to materials scientists. It has an International Advisory Editorial Board and an Editorial Committee. The Bulletin accords high importance to the quality of articles published and to keep at a minimum the processing time of papers submitted for publication.