Behzad Nasiri, Ghaffar Pasdar, Paul Zebrowski, Katharina Röser, David Naderer, Mario Waser
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引用次数: 0
Abstract
We herein report the asymmetric organocatalytic addition of azlactones to allenoates. Upon using chiral quaternary ammonium salt catalysts, i.e., Maruoka’s binaphthyl-based spirocyclic ammonium salts, the addition of various azlactones to allenoates proceeds in a β-selective manner with moderate levels of enantioselectivities (up to 83:17 er). Furthermore, the obtained products can be successfully engaged in nucleophilic ring opening reactions, thus giving highly functionalized α-amino acid derivatives.
Beilstein J. Org. Chem.2024,20, 1504–1509. doi:10.3762/bjoc.20.134
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