Biological Efficacy Evaluation of Lab Synthesized MgGA Bio-MOF as an Antioxidant Agent and Drug Vehicle

IF 2.7 4区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR Journal of Cluster Science Pub Date : 2024-07-03 DOI:10.1007/s10876-024-02650-9

Manu Sharma, Gagandeep Kaur, Pawan Kumar

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Abstract

In this work, a magnesium-based biomolecule metal organic framework (MgGA Bio-MOF) has been synthesized using magnesium chloride hexahydrate (MgCl₂.6H₂O) as a metal cation and an edible linker gallic acid (GA, C₆H₂(OH)₃CO₂H) as a organic building unit in water under certain experimental conditions. Initially, MgGA Bio-MOF synthesis has been confirmed through spectroscopic and microscopic analysis techniques. Afterwards, 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay has been performed to know the antioxidant activity of MOF. From the DPPH assay, it has been found that MgGA Bio-MOF possesses 70.4% scavenging activity. To proceed further, the drug release studies have been performed through IBU@MgGA Bio-MOF conjugate using UV- vis spectroscopy In investigation of drug release studies, we have observed 79% IBU released up to 150 min from IBU@MgGA Bio-MOF conjugate at neutral pH. After that, a constant absorbance has been observed, indicating the complete release of IBU. Overall, we found the selected BioMOF has excellent biological utility as an antioxidant agent as well as an anti-inflammatory drug carrier in line of its real-world applications

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实验室合成的 MgGA Bio-MOF 作为抗氧化剂和药物载体的生物药效评估

本研究以六水氯化镁（MgCl2.6H2O）为金属阳离子，以食用连接体没食子酸（GA，C6H2(OH)3CO2H）为有机构建单元，在一定的实验条件下于水中合成了镁基生物大分子金属有机框架（MgGA Bio-MOF）。首先，通过光谱和显微分析技术确认了 MgGA Bio-MOF 的合成。随后，进行了 2,2-二苯基-1-苦基肼（DPPH）测定，以了解 MOF 的抗氧化活性。通过 DPPH 试验发现，MgGA Bio-MOF 具有 70.4% 的清除活性。在药物释放研究中，我们观察到在中性 pH 值下，IBU@MgGA 生物-MOF 共轭物在 150 分钟内释放了 79% 的 IBU。此后，吸光度保持不变，表明 IBU 已完全释放。总之，我们发现所选的 BioMOF 作为抗氧化剂和抗炎药物载体具有很好的生物学效用，符合其在现实世界中的应用。

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来源期刊

Journal of Cluster Science 化学-无机化学与核化学

CiteScore

6.70

自引率

0.00%

发文量

166

审稿时长

3 months

期刊介绍： The journal publishes the following types of papers: (a) original and important research; (b) authoritative comprehensive reviews or short overviews of topics of current interest; (c) brief but urgent communications on new significant research; and (d) commentaries intended to foster the exchange of innovative or provocative ideas, and to encourage dialogue, amongst researchers working in different cluster disciplines.