In the Footsteps of Pasteur: Finding Conglomerates by Using State-of-the-Art Electron Diffraction

Abstract

Chiral discrimination in the solid state is crucial for chiral resolution and deracemization, which in turn determines the efficacy of pharmaceuticals and other chemicals. Several methods to identify conglomerates exist; however, the newest developments in electron diffraction are now capable of rapidly providing unambiguous information about the absolute structure, irrespective of whether these crystals consist of chiral or achiral molecules. It could rapidly evolve into an important tool to identify conglomerates for chiral resolution.