Effectiveness of Mindfulness-Based Cognitive Therapy on Depressive Symptoms, Brain Potential, and Neuroimmunoinflammatory Factors in Depressed Patients.

IF 0.8 4区医学 Q4 CLINICAL NEUROLOGY Clinical Neuropharmacology Pub Date : 2024-06-26 DOI:10.1097/WNF.0000000000000601

Jiancheng Qiu, Yifei Gong, Xiucui Zhang, Weibing Mao

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Abstract

Objective: This study was aimed to investigate the effectiveness of mindfulness-based cognitive therapy (MBCT) on depressive symptoms, brain potential, and neuroimmunoinflammatory factors in patients with depression.

Methods: Sixty-four eligible patients according to the inclusion criteria were randomly divided into the control group and the observation group, with 32 patients in each group. The control group received conventional therapy, while the observation group received MBCT on top of conventional therapy. The depressive symptoms, brain potential, and neuroimmunoinflammatory factors were measured in the two groups.

Results: After treatment, the Hamilton Depression Rating Scale score, tumor necrosis factor α, and interleukin-6 levels were decreased, while the World Health Organization Quality of Life Scale score, total number of response execution score, and 5-hydroxy tryptamine level were increased in both groups. Moreover, the Hamilton Depression Rating Scale score, tumor necrosis factor α, and interleukin-6 levels were decreased more significantly, while the World Health Organization Quality of Life Scale score, total number of response execution score, and 5-hydroxy tryptamine level were increased more significantly in the observation group compare to the control group (P < 0.01). In addition, the latency in the observation group was shorter and the amplitude was longer than those in the control group (P < 0.01).

Conclusions: Compared with conventional therapy, the use of MBCT combined with conventional therapy can effectively reduce depressive symptoms, suppresses inflammatory responses, and optimize attention and response to target stimulation and is worthy of wide clinical implementation.

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正念认知疗法对抑郁症患者抑郁症状、脑潜能和神经免疫炎症因子的影响

研究目的本研究旨在探讨正念认知疗法（MBCT）对抑郁症患者抑郁症状、脑潜能和神经免疫炎症因子的影响：根据纳入标准将 64 名符合条件的患者随机分为对照组和观察组，每组 32 人。对照组接受常规治疗，观察组在常规治疗的基础上接受 MBCT 治疗。对两组患者的抑郁症状、脑潜能和神经免疫炎症因子进行测量：结果：治疗后，两组患者的汉密尔顿抑郁量表评分、肿瘤坏死因子α和白细胞介素-6水平均有所下降，而世界卫生组织生活质量量表评分、反应执行总数评分和5-羟色胺水平均有所上升。此外，与对照组相比，观察组的汉密尔顿抑郁量表评分、肿瘤坏死因子α和白细胞介素-6水平下降更明显，而世界卫生组织生活质量量表评分、反应执行总数评分和5-羟色胺水平上升更明显（P＜0.01）。此外，观察组的潜伏期比对照组短，振幅比对照组长（P < 0.01）：结论：与传统疗法相比，MBCT与传统疗法相结合可有效减轻抑郁症状，抑制炎症反应，优化注意力和对目标刺激的反应，值得在临床上广泛应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neuropharmacology 医学-临床神经学

CiteScore

1.20

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical Neuropharmacology is a peer-reviewed journal devoted to the pharmacology of the nervous system in its broadest sense. Coverage ranges from such basic aspects as mechanisms of action, structure-activity relationships, and drug metabolism and pharmacokinetics, to practical clinical problems such as drug interactions, drug toxicity, and therapy for specific syndromes and symptoms. The journal publishes original articles and brief reports, invited and submitted reviews, and letters to the editor. A regular feature is the Patient Management Series: in-depth case presentations with clinical questions and answers.