Exploring the Potential of Glycolytic Modulation in Myeloid-Derived Suppressor Cells for Immunotherapy and Disease Management.

IF 4.3 4区 医学 Q2 IMMUNOLOGY Immune Network Pub Date : 2024-06-24 eCollection Date: 2024-06-01 DOI:10.4110/in.2024.24.e26
Jisu Kim, Jee Yeon Choi, Hyeyoung Min, Kwang Woo Hwang
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Abstract

Recent advancements in various technologies have shed light on the critical role of metabolism in immune cells, paving the way for innovative disease treatment strategies through immunometabolism modulation. This review emphasizes the glucose metabolism of myeloid-derived suppressor cells (MDSCs), an emerging pivotal immunosuppressive factor especially within the tumor microenvironment. MDSCs, an immature and heterogeneous myeloid cell population, act as a double-edged sword by exacerbating tumors or mitigating inflammatory diseases through their immune-suppressive functions. Numerous recent studies have centered on glycolysis of MDSC, investigating the regulation of altered glycolytic pathways to manage diseases. However, the specific changes in MDSC glycolysis and their exact functions continue to be areas of ongoing discussion yet. In this paper, we review a range of current findings, including the latest research on the alteration of glycolysis in MDSCs, the consequential functional alterations in these cells, and the outcomes of attempts to modulate MDSC functions by regulating glycolysis. Ultimately, we will provide insights into whether these research efforts could be translated into clinical applications.

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探索髓系衍生抑制细胞糖酵解调节在免疫疗法和疾病管理方面的潜力
各种技术的最新进展揭示了新陈代谢在免疫细胞中的关键作用,为通过免疫代谢调控创新疾病治疗策略铺平了道路。髓源性抑制细胞(MDSCs)是一种新出现的关键免疫抑制因子,尤其是在肿瘤微环境中。MDSCs是一种未成熟的异质性髓系细胞群,是一把双刃剑,通过其免疫抑制功能加剧肿瘤或减轻炎症性疾病。最近的许多研究都以 MDSC 的糖酵解为中心,调查糖酵解途径的改变对控制疾病的调节作用。然而,MDSC 糖酵解的具体变化及其确切功能仍是目前仍在讨论的领域。在本文中,我们将回顾目前的一系列研究成果,包括有关 MDSC 糖酵解改变的最新研究、这些细胞随之发生的功能改变以及试图通过调节糖酵解来调节 MDSC 功能的结果。最后,我们将深入探讨这些研究工作能否转化为临床应用。
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来源期刊
Immune Network
Immune Network Immunology and Microbiology-Immunology
CiteScore
2.90
自引率
3.30%
发文量
36
期刊介绍: Immune Network publishes novel findings in basic and clinical immunology and aims to provide a medium through which researchers in various fields of immunology can share and connect. The journal focuses on advances and insights into the regulation of the immune system and the immunological mechanisms of various diseases. Research that provides integrated insights into translational immunology is given preference for publication. All submissions are evaluated based on originality, quality, clarity, and brevity
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