Effects of Aerobic Training on Sex Hormones in A Cuprizone Rat Model of Multiple Sclerosis.

IF 2.3 Q2 OBSTETRICS & GYNECOLOGY International Journal of Fertility & Sterility Pub Date : 2024-06-09 DOI:10.22074/ijfs.2023.1987670.1427

Maryam Abbasi, Mohammadtaghi Farokhnezhad, Abdolhosein Taheri, Alireza Lotfi, Hadis Arghavanfar

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Abstract

Background: Central nervous system damage in multiple sclerosis (MS) leads to severe physical disability and neurological defects. Sexual dysfunction and infertility in patients with MS have often been neglected in previous studies. Aerobic exercise is suggested to improve circulating testosterone levels and sexual function. Therefore, the purpose of this study was to investigate the effect of aerobic exercise on sex hormone levels in a cuprizone rat model of MS.

Materials and methods: In this experimental study, 30 male rats (aged 70 days, 154.55 ± 18.1 g) were randomly divided into five groups: MS, exercise-MS (EX-MS), MS-EX, EX-MS-EX, and normal control (control). MS was induced by feeding cuprizone pellets (0.2%) to the rats for six weeks. The exercise groups performed an aerobic exercise protocol on a treadmill five days/week for six weeks before and during the induction of the MS model. Serum testosterone, follicle stimulating hormone (FSH), and luteinising hormone (LH) levels were measured using the ELISA method with standard kits (ZellBio Germany). Luxol fast blue staining (LFB) of the corpora collosa were performed.

Results: The results showed a significant decrease in the serum levels of testosterone, FSH, and LH in the MS groups compared to the control group (P<0.05). There was a significant increase in the serum levels of testosterone, FSH, and LH in the EX-MS-EX, and EX-MS groups compared to the MS group (P<0.05).

Conclusion: Aerobic exercise could improve the level of sex hormones in the cuprizone rat model of MS and may be used to attenuate sexual dysfunction in patients with MS.

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有氧训练对 Cuprizone 多发性硬化大鼠模型中性激素的影响

背景：多发性硬化症（MS）的中枢神经系统损伤会导致严重的身体残疾和神经缺陷。在以往的研究中，多发性硬化症患者的性功能障碍和不育症往往被忽视。有氧运动可改善循环睾酮水平和性功能。因此，本研究旨在探讨有氧运动对铜绿素多发性硬化症大鼠模型中性激素水平的影响：在这项实验研究中，30 只雄性大鼠（年龄 70 天，体重 154.55 ± 18.1 克）被随机分为五组：MS组、运动-MS（EX-MS）组、MS-EX组、EX-MS-EX组和正常对照组（对照组）。给大鼠喂食铜绿素颗粒（0.2%）诱导 MS，为期六周。在诱导 MS 模型之前和期间的六周内，运动组每周五天在跑步机上进行有氧运动。血清睾酮、促卵泡激素（FSH）和黄体生成素（LH）的水平是通过使用标准试剂盒（德国 ZellBio 公司）的 ELISA 方法测定的。对胶原体进行鲁索快蓝染色（LFB）：结果表明，与对照组（PC）相比，MS 组血清中的睾酮、FSH 和 LH 水平明显下降：有氧运动可改善铜绿素多发性硬化症大鼠模型的性激素水平，可用于缓解多发性硬化症患者的性功能障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Fertility & Sterility 医学-妇产科学

CiteScore

4.20

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： International Journal of Fertility & Sterility is a quarterly English publication of Royan Institute . The aim of the journal is to disseminate information through publishing the most recent scientific research studies on Fertility and Sterility and other related topics. Int J Fertil Steril has been certified by Ministry of Culture and Islamic Guidance in 2007 and was accredited as a scientific and research journal by HBI (Health and Biomedical Information) Journal Accreditation Commission in 2008. Int J Fertil Steril is an Open Access journal.