Menstrual Cycle Disturbances after COVID-19 Vaccination: A Cross-Sectional Study.

IF 2.3 Q2 OBSTETRICS & GYNECOLOGY International Journal of Fertility & Sterility Pub Date : 2024-06-09 DOI:10.22074/ijfs.2024.2016339.1579
Farima Rahimi Mansour, Amirreza Keyvanfar, Hanieh Najafiarab, Shaghayegh Hooshmand Chayijan, Farah Farzaneh, Golnoush Mortezaei
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Abstract

Background: Following COVID-19 vaccination, some women suffered from menstrual cycle disturbances. This study aimed to investigate menstrual cycle disturbances after COVID-19 vaccination in women of reproductive age.

Materials and methods: This cross-sectional study was performed on 407 vaccinated women in the vaccination center of Imam Hossein Hospital (Tehran, Iran) between October 2021 and October 2022. They were interviewed based on a research-made checklist which consisted of two areas of questions about the baseline characteristics of participants and menstrual cycle characteristics to explore menstrual characteristics following COVID-19 vaccination.

Results: The prevalence of menstrual disturbances was higher after the third dose (38.3%) compared with the second (27.9%) and first (17.7%) doses (P<0.001). After the first dose, a history of polycystic ovarian syndrome [PCOS, odds ratio (OR)=7.35, 95% confidential interval (CI)= (3.64-14.82), P<0.001] and menstrual disturbances with unknown etiology [OR=15.23, 95% CI=(6.30-36.80), P<0.001] could predict menstrual disturbances. After the second dose, a history of menstrual disturbances with unknown etiology [OR=3.83, 95% CI=(1.47-9.94), P=0.006] and menstrual disturbances after the first dose [OR=201.96, 95% CI= (40.99-994.90), P<0.001] were predictors of menstrual disturbances. After the third dose, a history of menstrual disturbances with unknown etiology [OR=3.09, 95% CI= (1.00-9.52), P=0.048], menstrual disturbances after the first [OR=9.82, 95% CI=(1.38-69.69), P=0.022] and second [OR=7.83, 95% CI=(1.46-41.92), P=0.016] doses could predict menstrual disturbances.

Conclusion: We detected that many women experienced various menstrual disturbances after vaccination against SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). Furthermore, a history of menstrual abnormalities (before COVID-19 vaccination and following the previous doses of these vaccines) was associated with developing menstrual disturbances.

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接种 COVID-19 疫苗后的月经周期紊乱:一项横断面研究
背景:接种COVID-19疫苗后,一些女性出现月经周期紊乱。本研究旨在调查育龄妇女接种 COVID-19 疫苗后月经周期紊乱的情况:这项横断面研究于 2021 年 10 月至 2022 年 10 月期间在伊玛目-侯赛因医院(伊朗德黑兰)的疫苗接种中心对 407 名接种过疫苗的妇女进行了调查。研究人员根据自制的调查表对她们进行了访谈,调查表包括两个方面的问题,即参与者的基线特征和月经周期特征,以探讨接种COVID-19疫苗后的月经特征:结果:与接种第二剂(27.9%)和第一剂(17.7%)相比,接种第三剂后月经紊乱的发生率更高(38.3%):我们发现,许多妇女在接种 SARS-CoV-2(严重急性呼吸系统综合征冠状病毒 2)疫苗后出现了各种月经紊乱。此外,月经异常史(接种 COVID-19 疫苗前和接种这些疫苗后)与月经紊乱有关。
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来源期刊
CiteScore
4.20
自引率
0.00%
发文量
68
审稿时长
>12 weeks
期刊介绍: International Journal of Fertility & Sterility is a quarterly English publication of Royan Institute . The aim of the journal is to disseminate information through publishing the most recent scientific research studies on Fertility and Sterility and other related topics. Int J Fertil Steril has been certified by Ministry of Culture and Islamic Guidance in 2007 and was accredited as a scientific and research journal by HBI (Health and Biomedical Information) Journal Accreditation Commission in 2008. Int J Fertil Steril is an Open Access journal.
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