Susceptibilities of phosphonoacetic acid and acyclovir resistant varicella-zoster virus mutants to 9-beta-arabinofuranosyladenine and 1-beta-arabinofuranosylcytosine.
K Shiraki, T Ogino, T Yamamoto, K Yamanishi, M Takahashi
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引用次数: 0
Abstract
The DNA polymerase activity, and susceptibilities to 9-beta-D-arabinofuranosyladenine(ara-A) and 1-beta-arabinofuranosylcytosine(ara-C) of a phosphonoacetic acid resistant mutant (PAA-R) of varicella-zoster virus (VZV) selected in the presence of PAA were examined. The DNA polymerase activity of PAA-R was inhibited less than that of the parent strain by PAA in vitro. PAA-R was resistant to acyclovir and also to both ara-A and ara-C. The susceptibilities to ara-A and ara-C of four acyclovir resistant mutants selected in the presence of acyclovir, and also resistant to PAA, were examined. Two variants were resistant, one was slightly resistant, and one was sensitive to both drugs. These cross-resistances and susceptibilities of VZV variants to PAA, ACV, ara-A and ara-C should be considered in chemotherapy of VZV infections.
测定了水痘-带状疱疹病毒(VZV)抗磷乙酸突变体(PAA- r)的DNA聚合酶活性和对9- β - d -阿拉伯糖醛酸苷(ara-A)和1- β -阿拉伯糖醛酸苷胞嘧啶(ara-C)的敏感性。PAA对PAA- r DNA聚合酶活性的抑制作用小于亲本菌株。PAA-R对阿昔洛韦耐药，对ara-A和ara-C也耐药。检测了在无环鸟苷存在下筛选出的4个抗无环鸟苷突变体对ara-A和ara-C的敏感性，并对PAA耐药。两种变体是耐药的，一种是轻微耐药的，另一种对两种药物都敏感。VZV变异体对PAA、ACV、ara-A和ara-C的交叉耐药和敏感性应在VZV感染的化疗中予以考虑。
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