Narrow Histopathological Margins are Acceptable in Surgical Resection of Basal Cell Carcinoma in Japanese: A Single-Center Retrospective Study.

IF 1.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL Journal of Nippon Medical School Pub Date : 2024-01-01 DOI:10.1272/jnms.JNMS.2024_91-308

Shun Miyazaki, Toshihiko Hoashi, Yuki Tone, Aeri Park, Saki Otani, Naoko Kanda, Hidehisa Saeki

{"title":"Narrow Histopathological Margins are Acceptable in Surgical Resection of Basal Cell Carcinoma in Japanese: A Single-Center Retrospective Study.","authors":"Shun Miyazaki, Toshihiko Hoashi, Yuki Tone, Aeri Park, Saki Otani, Naoko Kanda, Hidehisa Saeki","doi":"10.1272/jnms.JNMS.2024_91-308","DOIUrl":null,"url":null,"abstract":"Background: Basal cell carcinoma (BCC) is the most common cutaneous malignancy. BCCs occur mainly in exposed areas, such as the face and scalp. Therefore, surgical resection with narrow margins is highly desirable. However, narrow margins may increase the risk of positive histopathological margins. Outcomes for such treatment might be unfavorable, but evidence for such a conclusion is lacking.Methods: Between April 2015 and November 2023, a total of 230 Japanese cases with BCC which underwent surgical resection with 2-mm, 3-mm, or 5-mm margins were followed in our hospital. We conducted a retrospective review that focused on the recurrence rate and histopathological margins.Results: Recurrence was recorded if the follow-up time was longer than 3 months. One of the 198 cases (0.5%) developed a recurrence. The mean lateral and deep histopathological margins were 2,525.4 μm (30.8-14,034.6 μm) and 3,409 μm (199.9-16,523.6 μm), respectively. Recurrence rate was associated with tumor size and clinical tumor border. However, histopathological margin was not associated with recurrence rate, even when it was less than 1,000 μm.Conclusions: A narrow histopathological margin is acceptable for surgical resection of BCC in Japanese patients.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"91 3","pages":"296-306"},"PeriodicalIF":1.2000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nippon Medical School","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1272/jnms.JNMS.2024_91-308","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Basal cell carcinoma (BCC) is the most common cutaneous malignancy. BCCs occur mainly in exposed areas, such as the face and scalp. Therefore, surgical resection with narrow margins is highly desirable. However, narrow margins may increase the risk of positive histopathological margins. Outcomes for such treatment might be unfavorable, but evidence for such a conclusion is lacking.

Methods: Between April 2015 and November 2023, a total of 230 Japanese cases with BCC which underwent surgical resection with 2-mm, 3-mm, or 5-mm margins were followed in our hospital. We conducted a retrospective review that focused on the recurrence rate and histopathological margins.

Results: Recurrence was recorded if the follow-up time was longer than 3 months. One of the 198 cases (0.5%) developed a recurrence. The mean lateral and deep histopathological margins were 2,525.4 μm (30.8-14,034.6 μm) and 3,409 μm (199.9-16,523.6 μm), respectively. Recurrence rate was associated with tumor size and clinical tumor border. However, histopathological margin was not associated with recurrence rate, even when it was less than 1,000 μm.

Conclusions: A narrow histopathological margin is acceptable for surgical resection of BCC in Japanese patients.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

日本人可接受的基底细胞癌手术切除窄组织病理学边缘：单中心回顾性研究

背景：基底细胞癌（BCC）是最常见的皮肤恶性肿瘤：基底细胞癌（BCC）是最常见的皮肤恶性肿瘤。基底细胞癌主要发生在面部和头皮等暴露部位。因此，边缘狭窄的手术切除非常理想。然而，窄切缘可能会增加组织病理学切缘阳性的风险。这种治疗的结果可能是不利的，但目前还缺乏证据证明这一结论：方法：2015 年 4 月至 2023 年 11 月期间，我们医院共对 230 例日本 BCC 病例进行了随访，这些病例均接受了边缘为 2 毫米、3 毫米或 5 毫米的手术切除。我们对复发率和组织病理学切缘进行了回顾性分析：结果：如果随访时间超过 3 个月，则记录为复发。198例病例中有1例（0.5%）复发。组织病理学侧缘和深缘的平均值分别为 2,525.4 μm（30.8-14,034.6 μm）和 3,409 μm（199.9-16,523.6 μm）。复发率与肿瘤大小和临床肿瘤边界有关。然而，组织病理学边缘与复发率无关，即使边缘小于1,000 μm：结论：在日本患者中，手术切除 BCC 时可接受较窄的组织病理学切缘。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Journal of Nippon Medical School MEDICINE, GENERAL & INTERNAL-

CiteScore

1.80

自引率

10.00%

发文量

118

期刊介绍： The international effort to understand, treat and control disease involve clinicians and researchers from many medical and biological science disciplines. The Journal of Nippon Medical School (JNMS) is the official journal of the Medical Association of Nippon Medical School and is dedicated to furthering international exchange of medical science experience and opinion. It provides an international forum for researchers in the fields of bascic and clinical medicine to introduce, discuss and exchange thier novel achievements in biomedical science and a platform for the worldwide dissemination and steering of biomedical knowledge for the benefit of human health and welfare. Properly reasoned discussions disciplined by appropriate references to existing bodies of knowledge or aimed at motivating the creation of such knowledge is the aim of the journal.