Risk of suicide and suicide-related events in subjects treated with antiseizure medications.

IF 3.4 2区 医学 Q2 CLINICAL NEUROLOGY Expert Review of Neurotherapeutics Pub Date : 2024-09-01 Epub Date: 2024-07-08 DOI:10.1080/14737175.2024.2376110
Boulenouar Mesraoua, Francesco Brigo, Bassel Abou-Khalil, Musab Ali, Simona Lattanzi
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Abstract

Introduction: In the United States, it is reported that 1.4% of the general population commits suicide. It has been postulated that antiseizure medications (ASMs) can lead to the development of suicidal ideation and suicidal behavior; however, this risk is still very low and has yet to be precisely established.

Areas covered: This narrative review evaluates the risk of suicide-related events (SREs) in subjects taking ASMs for various neurological disorders. Screening tools for suicidal ideation and suicidal behavior are also discussed. References for this article were found using PubMed/MEDLINE.

Expert opinion: Although some ASMs can be associated with SREs, this is not yet clearly established. The mechanisms involved in suicide risk in subjects taking ASMs are multifactorial. The bidirectional relationship between depression and epilepsy, as well as other associations, should be kept in mind when interpreting any impact of ASMs in PWE. Screening for SREs, close monitoring of subjects taking ASMs are the most appropriate strategies to minimize suicide risk. More efforts should be made to achieve accurate risk stratification through prognostic models that could be applied to subjects taking ASMs. Studies exploring the association between ASMs and suicide should consider ASMs individually and control for prior SREs.

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接受抗癫痫药物治疗的受试者自杀和自杀相关事件的风险。
导言:据报道,美国有 1.4% 的普通人群自杀。据推测,抗癫痫药物(ASMs)可能会导致自杀意念和自杀行为的产生;然而,这种风险仍然很低,而且尚未得到确切证实:本综述评估了因各种神经系统疾病而服用 ASMs 的受试者发生自杀相关事件(SREs)的风险。文章还讨论了自杀意念和自杀行为的筛查工具。本文的参考文献是通过PubMed/MEDLINE找到的:尽管某些 ASM 可能与 SRE 相关,但这一点尚未得到明确证实。服用 ASMs 的受试者面临自杀风险的机制是多因素的。在解释ASMs对PWE的影响时,应牢记抑郁症和癫痫之间的双向关系以及其他关联。筛查 SRE、密切监测服用 ASMs 的受试者是将自杀风险降至最低的最适当策略。应做出更多努力,通过预后模型对服用 ASMs 的受试者进行准确的风险分层。探讨 ASMs 与自杀之间关系的研究应单独考虑 ASMs,并控制先前的 SRE。
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来源期刊
Expert Review of Neurotherapeutics
Expert Review of Neurotherapeutics Medicine-Neurology (clinical)
CiteScore
7.00
自引率
2.30%
发文量
61
审稿时长
4-8 weeks
期刊介绍: Expert Review of Neurotherapeutics (ISSN 1473-7175) provides expert reviews on the use of drugs and medicines in clinical neurology and neuropsychiatry. Coverage includes disease management, new medicines and drugs in neurology, therapeutic indications, diagnostics, medical treatment guidelines and neurological diseases such as stroke, epilepsy, Alzheimer''s and Parkinson''s. Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections: Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points
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