The therapeutic potential of phosphodiesterase 9 (PDE9) inhibitors: a patent review (2018-present).

IF 5.4 2区 医学 Q1 CHEMISTRY, MEDICINAL Expert Opinion on Therapeutic Patents Pub Date : 2024-09-01 Epub Date: 2024-07-09 DOI:10.1080/13543776.2024.2376632
Chen Zhang, Zhao-Hang Xue, Wei-Hao Luo, Mei-Yan Jiang, Yinuo Wu
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Abstract

Introduction: Phosphodiesterase 9 (PDE9) has been demonstrated as a potential target for neurological disorders and cardiovascular diseases, such as Alzheimer's disease and heart failure. For the last few years, a series of PDE9 inhibitors with structural diversities have been developed and patented by researchers and pharmaceutical companies, providing insights into first-in-class therapies of PDE9 drug candidates.

Area covered: This review provides an overview of PDE9 inhibitors in patents from 2018 to the present.

Expert opinion: Only a few of the current PDE9 inhibitors are highly selective over other PDEs, which limits their application in pharmacological and clinical research. The design and development of highly selective PDE9 inhibitors remain the top priority in future research. The advantages of targeting PDE9 rather than other PDEs in treating neurodegenerative diseases need to be explained thoroughly. Besides, application of PDE9 inhibitor-based combination therapies sheds light on treating diabetes and refractory heart diseases. Finally, PDE9 inhibitors should be further explored in clinical indications beyond neurological disorders and cardiovascular diseases.

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磷酸二酯酶 9(PDE9)抑制剂的治疗潜力:专利综述(2018 年至今)。
简介磷酸二酯酶9(PDE9)已被证明是神经系统疾病和心血管疾病(如阿尔茨海默病和心力衰竭)的潜在靶点。过去几年中,研究人员和制药公司开发了一系列结构多样化的 PDE9 抑制剂并申请了专利,为 PDE9 候选药物的一流疗法提供了启示:本综述概述了2018年至今的专利中的PDE9抑制剂.专家观点:本综述概述了2018年至今的专利中的PDE9抑制剂:目前的PDE9抑制剂中只有少数对其他PDE具有高选择性,这限制了它们在药理学和临床研究中的应用。设计和开发高选择性的PDE9抑制剂仍是未来研究的重中之重。在治疗神经退行性疾病方面,靶向 PDE9 而非其他 PDEs 的优势需要得到深入解释。此外,基于 PDE9 抑制剂的联合疗法在治疗糖尿病和难治性心脏病方面的应用也会带来启示。最后,除了神经系统疾病和心血管疾病之外,PDE9 抑制剂在临床适应症方面的应用也有待进一步探索。
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来源期刊
CiteScore
12.10
自引率
1.50%
发文量
50
审稿时长
6-12 weeks
期刊介绍: Expert Opinion on Therapeutic Patents (ISSN 1354-3776 [print], 1744-7674 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles on recent pharmaceutical patent claims, providing expert opinion the scope for future development, in the context of the scientific literature. The Editors welcome: Reviews covering recent patent claims on compounds or applications with therapeutic potential, including biotherapeutics and small-molecule agents with specific molecular targets; and patenting trends in a particular therapeutic area Patent Evaluations examining the aims and chemical and biological claims of individual patents Perspectives on issues relating to intellectual property The audience consists of scientists, managers and decision-makers in the pharmaceutical industry and others closely involved in R&D Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days.
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