Decreased DTI-ALPS index in delirium: a preliminary MRI study.

IF 2.4 3区医学 Q2 CLINICAL NEUROLOGY Neuroradiology Pub Date : 2024-10-01 Epub Date: 2024-07-09 DOI:10.1007/s00234-024-03415-x

Ye Tu, Renjie Song, Fei Xiong, Xiaoyun Fu

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Abstract

Purpose: Delirium is linked to brain abnormalities, yet the role of the glymphatic system is not well understood. This study aims to examine alterations in brain physiology in delirium by using diffusion-tensor imaging (DTI) to assess water diffusion along the perivascular space (ALPS) and to explore its correlation with clinical symptoms.

Methods: We examined 15 patients with delirium and 15 healthy controls, measuring water diffusion metrics along the x-, y-, and z-axes in both projection and association fibers to determine the DTI-ALPS index. We used a general linear model, adjusted for age and sex, to compare the DTI-ALPS index between groups. We also investigated the relationship between the DTI-ALPS index and clinical symptoms using partial correlations.

Results: Patients with delirium exhibited significantly lower DTI-ALPS indices compared to healthy controls (1.25 ± 0.15 vs. 1.38 ± 0.10, t = 2.903, p = 0.007; 1.27 ± 0.16 vs. 1.39 ± 0.08, 1.22 ± 0.16 vs. 1.37 ± 0.14, t = 2.617, p = 0.014; t = 2.719, p = 0.011; respectively). However, there was no significant correlation between the DTI-ALPS index and clinical symptoms.

Conclusion: Our findings indicate a decreased DTI-ALPS index in patients with delirium, suggesting potential alterations in brain physiology that may contribute to the pathophysiology of delirium. This study provides new insights into the mechanisms underlying delirium.

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谵妄患者的 DTI-ALPS 指数降低：一项初步磁共振成像研究。

目的：谵妄与大脑异常有关，但人们对甘油系统的作用还不甚了解。本研究旨在通过使用弥散张量成像（DTI）评估沿血管周围空间（ALPS）的水弥散，研究谵妄患者大脑生理学的改变，并探讨其与临床症状的相关性：我们对 15 名谵妄患者和 15 名健康对照者进行了检查，测量了投射纤维和关联纤维沿 x、y 和 z 轴的水弥散指标，以确定 DTI-ALPS 指数。我们使用一般线性模型，并根据年龄和性别进行调整，以比较不同组间的 DTI-ALPS 指数。我们还利用部分相关性研究了 DTI-ALPS 指数与临床症状之间的关系：结果：与健康对照组相比，谵妄患者的 DTI-ALPS 指数明显较低（分别为 1.25 ± 0.15 vs. 1.38 ± 0.10，t = 2.903，p = 0.007；1.27 ± 0.16 vs. 1.39 ± 0.08，1.22 ± 0.16 vs. 1.37 ± 0.14，t = 2.617，p = 0.014；t = 2.719，p = 0.011；）。然而，DTI-ALPS指数与临床症状之间没有明显的相关性：结论：我们的研究结果表明，谵妄患者的DTI-ALPS指数降低，这表明大脑生理可能发生了改变，而这种改变可能是谵妄的病理生理学原因之一。这项研究为了解谵妄的内在机制提供了新的视角。

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来源期刊

Neuroradiology 医学-核医学

CiteScore

5.30

自引率

3.60%

发文量

214

审稿时长

4-8 weeks

期刊介绍： Neuroradiology aims to provide state-of-the-art medical and scientific information in the fields of Neuroradiology, Neurosciences, Neurology, Psychiatry, Neurosurgery, and related medical specialities. Neuroradiology as the official Journal of the European Society of Neuroradiology receives submissions from all parts of the world and publishes peer-reviewed original research, comprehensive reviews, educational papers, opinion papers, and short reports on exceptional clinical observations and new technical developments in the field of Neuroimaging and Neurointervention. The journal has subsections for Diagnostic and Interventional Neuroradiology, Advanced Neuroimaging, Paediatric Neuroradiology, Head-Neck-ENT Radiology, Spine Neuroradiology, and for submissions from Japan. Neuroradiology aims to provide new knowledge about and insights into the function and pathology of the human nervous system that may help to better diagnose and treat nervous system diseases. Neuroradiology is a member of the Committee on Publication Ethics (COPE) and follows the COPE core practices. Neuroradiology prefers articles that are free of bias, self-critical regarding limitations, transparent and clear in describing study participants, methods, and statistics, and short in presenting results. Before peer-review all submissions are automatically checked by iThenticate to assess for potential overlap in prior publication.