Experimental and numerical characterization of screw elements used in twin-screw extrusion.

IF 2.6 4区 医学 Q2 PHARMACOLOGY & PHARMACY Pharmaceutical Development and Technology Pub Date : 2024-09-01 Epub Date: 2024-07-16 DOI:10.1080/10837450.2024.2378323
Vanessa Düphans, Vincent Kimmel, Lukas Messing, Gerhard Schaldach, Markus Thommes
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Abstract

Hot melt extrusion by a co-rotating twin screw extruder is an important process in the pharmaceutical industry. Especially for quality by design aspects, a comprehensive process understanding is indispensable. The performance of conveying elements was determined as critical process parameter, and therefore an experimental and numerical framework was developed to analyze and compare variations. A test rig capable of measuring volume flow, pressure and torque with high accuracy and precision was designed and built. The 3D simulation was performed using computational fluid dynamics (CFD). A stationary model with impulse transmission and an apparent motion of the screws was applied. The experimental data were fitted to the model of Pawlowski, and parameters for the pressure (A1, A2) and power characteristics (B1, B2) were determined. Good agreement between experimental data and the model was observed. The simulation was significantly faster compared to common methods, and the results were consistent with the literature. Systematic investigations of a native and worn screw were performed with CFD resulting in a transport capacity increase and a pressure build up decrease for all tested screw elements. An experimental and simulation setup was generated to assess the performance of co-rotating twin screw elements. The experiments provided high-quality data, and the simulations exhibited high flexibility with low computational effort.

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双螺杆挤压工艺中所用螺杆元件的实验和数值特性分析
使用同向旋转双螺杆挤出机进行热熔挤出是制药行业的一项重要工艺。特别是在设计质量方面,全面了解工艺流程是必不可少的。输送元件的性能被确定为关键工艺参数,因此开发了一个实验和数值框架来分析和比较各种变化。设计并建造了一个能够高精度测量体积流量、压力和扭矩的试验台。使用计算流体动力学(CFD)进行了三维模拟。应用了一个具有脉冲传输和螺杆表观运动的静态模型。实验数据与 Pawlowski 模型相拟合,并确定了压力(A1、A2)和功率特性(B1、B2)参数。实验数据与模型之间的一致性很好。与普通方法相比,模拟速度明显加快,结果与文献一致。利用 CFD 对原生螺杆和磨损螺杆进行了系统研究,结果表明所有测试的螺杆元件的输送能力都有所提高,压力积聚也有所降低。为评估同向旋转双螺杆元件的性能,建立了实验和模拟装置。实验提供了高质量的数据,而模拟则以较低的计算量展现了较高的灵活性。
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来源期刊
CiteScore
5.90
自引率
2.90%
发文量
82
审稿时长
1 months
期刊介绍: Pharmaceutical Development & Technology publishes research on the design, development, manufacture, and evaluation of conventional and novel drug delivery systems, emphasizing practical solutions and applications to theoretical and research-based problems. The journal aims to publish significant, innovative and original research to advance the frontiers of pharmaceutical development and technology. Through original articles, reviews (where prior discussion with the EIC is encouraged), short reports, book reviews and technical notes, Pharmaceutical Development & Technology covers aspects such as: -Preformulation and pharmaceutical formulation studies -Pharmaceutical materials selection and characterization -Pharmaceutical process development, engineering, scale-up and industrialisation, and process validation -QbD in the form a risk assessment and DoE driven approaches -Design of dosage forms and drug delivery systems -Emerging pharmaceutical formulation and drug delivery technologies with a focus on personalised therapies -Drug delivery systems research and quality improvement -Pharmaceutical regulatory affairs This journal will not consider for publication manuscripts focusing purely on clinical evaluations, botanicals, or animal models.
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