Pharmabiotic/phytobiotic formulas approach and their intravaginal effect on different parameters.

IF 1.8 3区 农林科学 Q2 VETERINARY SCIENCES Veterinary Research Communications Pub Date : 2024-10-01 Epub Date: 2024-07-09 DOI:10.1007/s11259-024-10450-9
María Hortencia Miranda, María Elena Fátima Nader-Macías
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Abstract

Postpartum reproductive infections in cows generate significant economic losses. The use of lactic acid bacteria in animal health is an alternative tool to avoid antibiotic therapy in the prevention/treatment of bovine reproductive infections. In previous studies, 6 lactic bacteria from bovine mammary glands and vagina with beneficial, safe and technological characteristics were selected, and included in probiotic/phytobiotic formulas (combined with Malva and Lapacho extracts). In this work, probiotic and phytobiotic formulations were designed and their long-term viability determined. They were administered intravaginally to 30 females pregnant bovine pre and postpartum. The modification of the native microbiota and permanence/colonization of cultivable bacteria was evaluated, and also the safety of the designed products through the application of nutritional, clinical, hematological and biochemical parameters. The microorganisms maintained their viability up to 9 months at refrigeration temperature. The number of cultivable bacteria showed different pattern: total aerobic mesophylls increased slightly in all experimental groups, while Enterobacteriaceae increased after delivery, except in beneficial acid lactic bacteria + vegetable extract cows. Control and vegetable extract females showed the highest numbers of Enterobacteriaceae at the end of the trial (30 days postpartum). The number of lactic acid bacteria increased significantly in all the groups between 15 days pre and postpartum. The different parameters evaluated demonstrate the safety and harmlessness of the designed formulas, without producing local and systemic adverse effects in the cows.

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药用生物/植物生物配方及其对不同参数的阴道内影响。
奶牛产后生殖感染会造成重大经济损失。在动物保健中使用乳酸菌是预防/治疗牛生殖感染时避免使用抗生素治疗的一种替代工具。在之前的研究中,从牛乳腺和阴道中筛选出了 6 种有益、安全且具有技术特点的乳酸菌,并将其纳入益生菌/植物抗生素配方(与麦芽和腊肠提取物结合使用)。在这项工作中,设计了益生菌和植物生物配方,并测定了它们的长期存活率。在产前和产后,对 30 头雌性怀孕牛进行阴道内给药。通过营养、临床、血液学和生化参数的应用,对本地微生物群的改变和可培养细菌的持久性/定殖进行了评估,并对所设计产品的安全性进行了评估。微生物在冷藏温度下的存活时间长达 9 个月。可培养细菌的数量呈现出不同的模式:除有益酸性乳酸菌+蔬菜提取物奶牛外,所有实验组的需氧中球菌总数都略有增加,而肠杆菌科在分娩后有所增加。在试验结束时(产后 30 天),对照组和蔬菜提取物组母牛的肠杆菌数量最多。在产前 15 天和产后 15 天之间,所有组别的乳酸菌数量都有显著增加。所评估的不同参数表明,所设计的配方安全无害,不会对奶牛的局部和全身产生不良影响。
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来源期刊
Veterinary Research Communications
Veterinary Research Communications 农林科学-兽医学
CiteScore
2.50
自引率
0.00%
发文量
173
审稿时长
3 months
期刊介绍: Veterinary Research Communications publishes fully refereed research articles and topical reviews on all aspects of the veterinary sciences. Interdisciplinary articles are particularly encouraged, as are well argued reviews, even if they are somewhat controversial. The journal is an appropriate medium in which to publish new methods, newly described diseases and new pathological findings, as these are applied to animals. The material should be of international rather than local interest. As it deliberately seeks a wide coverage, Veterinary Research Communications provides its readers with a means of keeping abreast of current developments in the entire field of veterinary science.
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