Seroprevalence of human brucellosis in Turkey: A comprehensive meta-analysis

IF 2.4 2区农林科学 Q3 INFECTIOUS DISEASES Zoonoses and Public Health Pub Date : 2024-07-08 DOI:10.1111/zph.13166

Pınar Kıran, Reyhan Uçku

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Abstract

Aims

Brucellosis remains a common zoonotic disease, in developing countries, as well as in Turkey where it is endemic, underdiagnosed, and underreported. The aim of this meta-analysis was to provide a comprehensive estimate of seroprevalence with a large sample size, covering all regions of Turkey, including both grey literature and published studies.

Methods and Results

A systematic search was performed in MEDLINE (via PubMed), TürkMedline (National Health Sciences-Periodicals Database), and YÖKSİS database (Higher Education Council Information System) until May 5th, 2023. The quality of the studies was evaluated independently using Joanna Briggs Institute (JBI) critical assessment tool for prevalence studies. A random-effects model (DerSimion and Laird) was utilized to estimate the overall pooled prevalence. A sensitivity analysis was performed, excluding studies with a high risk of bias. The subgroup analyses and meta-regression were conducted to explore sources of heterogeneity. Egger test and funnel plot were used to assess publication bias. The meta-analysis included 30 studies in total published between 1999 and 2021 with 51,560 individuals. In Turkey, the pooled seroprevalence of human brucellosis was estimated to be 4.5% (95% confidence interval [CI]: 3.8%–5.3%). According to the subgroup analysis, a higher seroprevalence was found in rural areas (8.0%, 95% CI: 5.4%–10.7%), high-risk occupational groups (9.9%, 95% CI: 5.3%–14.6%), and the Central East Anatolia Region (13%, 95% CI: 3.2%–22.8%). The meta-regression analysis identified living in rural areas and certain geographic regions as significant risk factors associated with higher seroprevalence.

Conclusions

This meta-analysis revealed a significant burden of human brucellosis in Turkey. The findings highlight the need for public health measures and targeted interventions to reduce the burden of this zoonotic disease, especially in rural areas, high-risk occupational groups, and the East Anatolia Region.

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土耳其人类布鲁氏菌病的血清流行率：综合荟萃分析。

目的：在发展中国家和土耳其，布鲁氏菌病仍然是一种常见的人畜共患疾病，在土耳其布鲁氏菌病流行、诊断和报告不足。这项荟萃分析的目的是提供一个覆盖土耳其所有地区、样本量大的血清流行率综合估计值，其中包括灰色文献和已发表的研究：在MEDLINE（通过PubMed）、TürkMedline（国家健康科学期刊数据库）和YÖKSİS数据库（高等教育委员会信息系统）中进行了系统检索，检索期至2023年5月5日。研究质量采用乔安娜-布里格斯研究所（JBI）的流行病学研究关键评估工具进行独立评估。采用随机效应模型（DerSimion 和 Laird）来估算总体汇总流行率。进行了敏感性分析，排除了偏倚风险较高的研究。进行了亚组分析和元回归，以探索异质性的来源。Egger 检验和漏斗图用于评估发表偏倚。荟萃分析共纳入了 30 项研究，这些研究发表于 1999 年至 2021 年之间，涉及 51 560 人。在土耳其，人类布鲁氏菌病的汇总血清流行率估计为4.5%（95%置信区间[CI]：3.8%-5.3%）。根据亚组分析，农村地区（8.0%，95% CI：5.4%-10.7%）、高风险职业群体（9.9%，95% CI：5.3%-14.6%）和中东安纳托利亚地区（13%，95% CI：3.2%-22.8%）的血清流行率较高。荟萃回归分析表明，居住在农村地区和某些地理区域是血清阳性率较高的重要风险因素：这项荟萃分析表明，土耳其的人类布鲁氏菌病负担沉重。研究结果突出表明，有必要采取公共卫生措施和有针对性的干预措施来减轻这种人畜共患病的负担，尤其是在农村地区、高风险职业群体和东安纳托利亚地区。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Zoonoses and Public Health 医学-传染病学

CiteScore

5.30

自引率

4.20%

发文量

115

审稿时长

6-12 weeks

期刊介绍： Zoonoses and Public Health brings together veterinary and human health researchers and policy-makers by providing a venue for publishing integrated and global approaches to zoonoses and public health. The Editors will consider papers that focus on timely collaborative and multi-disciplinary research in zoonoses and public health. This journal provides rapid publication of original papers, reviews, and potential discussion papers embracing this collaborative spirit. Papers should advance the scientific knowledge of the sources, transmission, prevention and control of zoonoses and be authored by scientists with expertise in areas such as microbiology, virology, parasitology and epidemiology. Articles that incorporate recent data into new methods, applications, or approaches (e.g. statistical modeling) which enhance public health are strongly encouraged.