Palladium-Catalyzed Selective γ-Monoarylation of Free Amines Containing Symmetric γ-C-H Controlled by a Transient Directing Group.

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC Organic Letters Pub Date : 2024-07-26 Epub Date: 2024-07-10 DOI:10.1021/acs.orglett.4c01968

Sifan Dong, Xinghao Cai, Chen Ma, Haolong Li, Ying Kang, Juan Feng, Shiming Fan, Shouxin Liu

引用次数: 0

Abstract

We developed a new transient directing group, N-(2-benzoyl-4-chlorophenyl)-1,1,1-trifluoromethanesulfonamide, which can facilitate the γ-monoarylation of free amines containing symmetric γ-C-H bonds. A variety of amines containing symmetric and identical γ-C(sp³)-H and γ-C(sp²)-H reacted with a diverse range of aryl and heteroaryl iodides to provide γ-monoarylated products exclusively.

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钯催化的由瞬时引导基团控制的含对称 γ-C-H 的游离胺的γ-单芳基化反应。

我们开发了一种新的瞬时指导基团 N-(2-苯甲酰基-4-氯苯基)-1,1,1-三氟甲磺酰胺，它可以促进含有对称 γ-C-H 键的游离胺的γ-单芳基化反应。多种含有对称且相同的 γ-C(sp3)-H 和 γ-C(sp2)-H 的胺与多种芳基和杂芳基碘化物发生反应，生成了 γ 单芳基化产物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.