Pd-Catalyzed Aerobic Synthesis of Allylic Sulfones from Allylic Alcohols and Sulfonyl Hydrazines in Water

IF 3.3 2区 化学 Q1 CHEMISTRY, ORGANIC The Journal of Organic Chemistry Pub Date : 2024-07-10 DOI:10.1021/acs.joc.4c00882
Jing Yu*, Xiaoyu Yan, Yuying Chen, Kexin Guo, Shuo Wang and Xiantao Ma*, 
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Abstract

A mild and green synthesis of allylic sulfones from allylic alcohols and sulfonyl hydrazines was developed in water media. The simple and commercially available Pd(PPh3)4 is used as the best catalyst, and the reaction can proceed smoothly at 40 °C under air. This new method does not require the common nitrogen protection and organic media, and can be readily scaled up in gram scale, showing the good practicality value.

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钯催化水中烯丙基醇和磺酰肼烯丙基砜的有氧合成。
本研究开发了一种在水介质中以烯丙基醇和磺酰肼为原料合成烯丙基砜的温和绿色方法。该方法使用简单且市场上可买到的 Pd(PPh3)4 作为最佳催化剂,反应可在 40 °C 的空气中顺利进行。这种新方法不需要常见的氮气保护和有机介质,而且可以很容易地按克级放大,显示了良好的实用价值。
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来源期刊
The Journal of Organic Chemistry
The Journal of Organic Chemistry 化学-有机化学
CiteScore
6.20
自引率
11.10%
发文量
1467
审稿时长
2 months
期刊介绍: The Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.
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