Xiang Li Sr, Wen Liu, Guannan Jiang, Jinrong Lian, Yi Zhong, Jialei Zhou, Haiying Li, Xingshun Xu, Yaobo Liu, Cong Cao, Jin Tao, Jian Cheng, John H. Zhang, Gang Chen
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引用次数: 0
Abstract
Adv. Sci. 2024, e2307556.
https://doi.org/10.1002/advs.202307556
Figure 5 Enrichment analysis to identify potential target signaling pathway for celastrol on neurons. A) Rbfox3 was used as a marker for neurons. B) 3D-Principal component analysis (PCA) was employed to identify the subclusters with the highest variance. C) The strength of interactions between neuron 8 and other cell types was evaluated through CellChat analysis of intercellular communication. D) The analysis of cell–cell communication was performed using CellChat to demonstrate the quantification of interactions between neuron 8 and other cellular populations. E) The volcano plot illustrates the differential expression of genes between the ICH+Cel group and the ICH+vehicle group. F) A Gene Ontology (GO) enrichment analysis was performed to identify potential signaling pathways regulated by celastrol following ICH, with an average log2 fold change >0.25. G) Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis was conducted to identify potential signaling pathways regulated by celastrol following ICH, with an average log2 fold change >0.25.
These changes do not affect the results or conclusions of this study. The authors apologize for any inconvenience caused.
期刊介绍:
Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.