Correction to “Celastrol Ameliorates Neuronal Mitochondrial Dysfunction Induced by Intracerebral Hemorrhage via Targeting cAMP-Activated Exchange Protein-1”

IF 14.1 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Advanced Science Pub Date : 2024-07-10 DOI:10.1002/advs.202406154
Xiang Li Sr, Wen Liu, Guannan Jiang, Jinrong Lian, Yi Zhong, Jialei Zhou, Haiying Li, Xingshun Xu, Yaobo Liu, Cong Cao, Jin Tao, Jian Cheng, John H. Zhang, Gang Chen
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引用次数: 0

Abstract

Adv. Sci. 2024, e2307556.

https://doi.org/10.1002/advs.202307556

Figure 5 Enrichment analysis to identify potential target signaling pathway for celastrol on neurons. A) Rbfox3 was used as a marker for neurons. B) 3D-Principal component analysis (PCA) was employed to identify the subclusters with the highest variance. C) The strength of interactions between neuron 8 and other cell types was evaluated through CellChat analysis of intercellular communication. D) The analysis of cell–cell communication was performed using CellChat to demonstrate the quantification of interactions between neuron 8 and other cellular populations. E) The volcano plot illustrates the differential expression of genes between the ICH+Cel group and the ICH+vehicle group. F) A Gene Ontology (GO) enrichment analysis was performed to identify potential signaling pathways regulated by celastrol following ICH, with an average log2 fold change >0.25. G) Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis was conducted to identify potential signaling pathways regulated by celastrol following ICH, with an average log2 fold change >0.25.

These changes do not affect the results or conclusions of this study. The authors apologize for any inconvenience caused.

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Celastrol 通过靶向 cAMP-Activated Exchange Protein-1 改善脑出血诱发的神经元线粒体功能障碍》的更正。
Adv. Sci. 2024, e2307556.https://doi.org/10.1002/advs.202307556Figure 5 通过富集分析确定仙客来对神经元的潜在靶信号通路。A) Rbfox3 被用作神经元的标记。B) 采用三维主成分分析(PCA)确定方差最大的亚簇。C) 通过 CellChat 细胞间通讯分析评估了神经元 8 与其他细胞类型之间的相互作用强度。D) 利用 CellChat 对细胞间通讯进行分析,以展示神经元 8 与其他细胞群之间的相互作用的量化。E) 火山图显示了 ICH+Cel 组和 ICH+vehicle 组基因表达的差异。F) 进行了基因本体(GO)富集分析,以确定 ICH 后受 Celastrol 调控的潜在信号通路,平均 log2 折合变化为 0.25。G)进行了京都基因组百科全书(KEGG)通路分析,以确定 ICH 后受赛拉司特醇调控的潜在信号通路,平均 log2 折变化为 0.25。作者对由此造成的不便深表歉意。
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来源期刊
Advanced Science
Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY
CiteScore
18.90
自引率
2.60%
发文量
1602
审稿时长
1.9 months
期刊介绍: Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.
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