Evaluation of atopic diseases in patients with allergic contact dermatitis.

IF 2.6 3区 医学 Q2 ALLERGY Allergy and asthma proceedings Pub Date : 2024-07-01 DOI:10.2500/aap.2024.45.240019
Ashley Sandoval, Yela Jung, Iris Kim, Nina Sadigh, Jimmy Kwon, Yesim Yilmaz Demirdag, Asal Gharib Naderi, Tiffany Jean
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Abstract

Background: There is controversy on whether allergic contact dermatitis (ACD) is associated with atopy. Research on eczema and the risk of ACD is mixed, and there is sparse literature on other atopic conditions. Objective: Our study examined the prevalence of several atopic conditions, including allergic rhinitis, eczema, asthma, and food allergies in patients with ACD, and compared these to patients without ACD. Methods: We retrospectively reviewed adult patients ages ≥ 18 years with ACD (n = 162) with positive patch testing results and documented any history of atopy, including childhood eczema, asthma, allergic rhinitis, and immunoglobulin E-mediated food allergy. The prevalence of atopic conditions was compared between our ACD cohort and controls without ACD (n = 163) from our electronic medical records system (age and gender matched). Results: Among our patients with ACD, 53 (33%) had allergic rhinitis, 22 (14%) had childhood eczema, 32 (20%) had asthma, and 8 (5%) had food allergies. We observed that the odds of atopy overall (n = 76) in the ACD group compared with the control group were increased (odds ratio [OR] 1.88; p = 0.007). Allergic rhinitis was the highest risk factor (n = 53) with an OR of 12.64 (p < 0.001). Childhood eczema (n = 22) was also increased in the ACD group (OR 2.4; p = 0.026). The odds of asthma and food allergy in the ACD group were also increased; however, the difference was not statistically significant from the control group (OR 1.76 [p = 0.071] and OR 2.76 [p = 0.139], respectively). Conclusion: Patients with ACD had increased odds of eczema, allergic rhinitis, and atopic conditions overall. Asthma and food allergies were not found to have a statistically significant correlation. Larger studies that delve into atopic risk factors in ACD would be important to confirm these findings.

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评估过敏性接触性皮炎患者的特应性疾病。
背景:关于过敏性接触性皮炎(ACD)是否与特应性相关还存在争议。有关湿疹和 ACD 风险的研究结果不一,而有关其他特应性疾病的文献则很少。研究目的我们的研究调查了过敏性接触性皮炎患者中过敏性鼻炎、湿疹、哮喘和食物过敏等几种特应性疾病的发病率,并将其与非过敏性接触性皮炎患者进行了比较。方法:我们回顾性地检查了年龄≥ 18 岁、斑贴试验结果呈阳性的成人 ACD 患者(n = 162),并记录了任何特应性病史,包括儿童湿疹、哮喘、过敏性鼻炎和免疫球蛋白 E 介导的食物过敏。我们将特应性疾病的发病率与来自电子病历系统(年龄和性别匹配)的无特应性疾病对照组(n = 163)进行了比较。结果显示在 ACD 患者中,53 人(33%)患有过敏性鼻炎,22 人(14%)患有儿童湿疹,32 人(20%)患有哮喘,8 人(5%)患有食物过敏。我们观察到,与对照组相比,ACD 组患上过敏性鼻炎的几率(n = 76)有所增加(几率比 [OR] 1.88;p = 0.007)。过敏性鼻炎是最高的风险因素(n = 53),OR 值为 12.64(p 结论:ACD 患者患过敏性鼻炎的几率比对照组高:总体而言,ACD 患者患湿疹、过敏性鼻炎和特应性疾病的几率增加。哮喘和食物过敏在统计学上没有明显的相关性。对 ACD 特应性风险因素进行更大规模的研究对于证实这些发现非常重要。
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来源期刊
CiteScore
5.70
自引率
35.70%
发文量
106
审稿时长
6-12 weeks
期刊介绍: Allergy & Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists. The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma. Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.
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