Evaluation of Triglyceride-Glucose Index Elevation as a Biomarker and Risk Factor in Laryngeal Squamous Cell Carcinoma

IF 1.7 4区医学 Q2 OTORHINOLARYNGOLOGY Clinical Otolaryngology Pub Date : 2024-07-09 DOI:10.1111/coa.14197

Remzi Dogan, Ramazan Bahadir Kucuk, Selahattin Tugrul, Alper Yenigun, Omer Faruk Calim, Elif Ece Dogan, Emre Polat, Orhan Ozturan

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Abstract

Objectives

Insulin resistance is associated with increased levels of IGF-1. IGF-1 has been shown to increase the risk of laryngeal squamous cell carcinoma. The Triglyceride-glucose index (TyG index) is a marker of insulin resistance. Our study aimed to investigate the relationship between the TyG index and laryngeal squamous cell carcinoma.

Design

Retrospective cohort study.

Setting

Two tertiary care academic hospitals.

Methods

The study included 53 patients with laryngeal squamous cell carcinoma (Group 1) and 48 healthy volunteers (Group 2). Laryngeal cancer patients were divided into two groups according to their stage. Stages I and II were named Group 1A, and Stages III and IV were called Group 1B. The TyG index was calculated as ln [fasting Triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2]. The effect of the TyG index on laryngeal cancer was investigated on the parameters of sex, age, body mass index, and stage of the disease.

Results

There were no significant differences in age, sex, and BMI between the groups. The TyG index of group 1 (4.75 ± 0.33) was significantly higher than that of group 2 (4.59 ± 0.15). The TyG index value of group 1B (4.84 ± 0.31) was significantly higher than both group 1A (4.61 ± 0.32) and group 2 (4.59 ± 0.15). There was no significant difference between the TyG index values of group 1A (4.61 ± 0.32) and group 2 (4.59 ± 0.15).

Conclusion

The TyG index may be a promising laryngeal squamous cell carcinoma biomarker. People with a higher TyG index may have a higher incidence of laryngeal squamous cell carcinoma and a higher risk of progression.

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评估甘油三酯-葡萄糖指数升高作为喉鳞状细胞癌生物标志物和风险因素的作用

目的：胰岛素抵抗与 IGF-1 水平升高有关。研究表明，IGF-1 会增加喉鳞状细胞癌的发病风险。甘油三酯-葡萄糖指数（TyG 指数）是胰岛素抵抗的标志物。我们的研究旨在探讨TyG指数与喉鳞状细胞癌之间的关系：设计：回顾性队列研究：地点：两家三级医疗学术医院：研究包括53名喉鳞癌患者（第1组）和48名健康志愿者（第2组）。喉癌患者按分期分为两组。I期和II期称为1A组，III期和IV期称为1B组。TyG 指数的计算公式为 ln [空腹甘油三酯（毫克/分升）×空腹血浆葡萄糖（毫克/分升）/2]。根据性别、年龄、体重指数和疾病分期等参数，研究了TyG指数对喉癌的影响：结果：各组之间在年龄、性别和体重指数方面无明显差异。第 1 组的 TyG 指数（4.75 ± 0.33）明显高于第 2 组（4.59 ± 0.15）。1B 组的 TyG 指数值（4.84 ± 0.31）明显高于 1A 组（4.61 ± 0.32）和 2 组（4.59 ± 0.15）。1A组（4.61 ± 0.32）和2组（4.59 ± 0.15）的TyG指数值无明显差异：结论：TyG指数可能是一种有前景的喉鳞癌生物标志物。结论：TyG指数越高，喉鳞状细胞癌的发病率越高，病情恶化的风险也越大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Otolaryngology 医学-耳鼻喉科学

CiteScore

4.00

自引率

4.80%

发文量

106

审稿时长

>12 weeks

期刊介绍： Clinical Otolaryngology is a bimonthly journal devoted to clinically-oriented research papers of the highest scientific standards dealing with: current otorhinolaryngological practice audiology, otology, balance, rhinology, larynx, voice and paediatric ORL head and neck oncology head and neck plastic and reconstructive surgery continuing medical education and ORL training The emphasis is on high quality new work in the clinical field and on fresh, original research. Each issue begins with an editorial expressing the personal opinions of an individual with a particular knowledge of a chosen subject. The main body of each issue is then devoted to original papers carrying important results for those working in the field. In addition, topical review articles are published discussing a particular subject in depth, including not only the opinions of the author but also any controversies surrounding the subject. • Negative/null results In order for research to advance, negative results, which often make a valuable contribution to the field, should be published. However, articles containing negative or null results are frequently not considered for publication or rejected by journals. We welcome papers of this kind, where appropriate and valid power calculations are included that give confidence that a negative result can be relied upon.