Joint health and pain in the changing hemophilia treatment landscape.

IF 2.3 4区医学 Q2 HEMATOLOGY Expert Review of Hematology Pub Date : 2024-08-01 Epub Date: 2024-07-15 DOI:10.1080/17474086.2024.2378936

Maria Elisa Mancuso, Paul McLaughlin, Angela L Forsyth, Leonard A Valentino

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Abstract

Introduction: Hemophilia is an inherited bleeding disorder. Bleeding, and in particular joint hemorrhage results in chronic arthropathy and disability. Acute and chronic pain are frequent and limit activity and participation and result in decreased health-related quality of life. Remarkable progress has been made in the diagnosis and treatment of hemophilia but bleeding continues to prove recalcitrant to currently available treatments and joint disease remains problematic. Physiotherapy and pain management are mainstays of current multidisciplinary integrated care of people with hemophilia (PWH). The focus of this review is on preservation of joint health in the era of new and innovative therapies.

Areas covered: A search of the PubMed Central was conducted on 1 February 2024 using the MeSH Major Topic terms identified as keywords for the manuscript. This review will highlight what is known and unknown about joint bleeding and arthropathy, including insights on pain as a related complication.

Expert opinion: Recent advances in therapeutic interventions aimed at promoting healthy joints in PWH will be discussed, including both the pharmacological treatment landscape and related strategies to promote joint health.

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不断变化的血友病治疗环境中的关节健康和疼痛。

简介：血友病是一种遗传性出血性疾病：血友病是一种遗传性出血性疾病。出血，尤其是关节出血会导致慢性关节病和残疾。急性和慢性疼痛经常发生，限制了患者的活动和参与，导致与健康相关的生活质量下降。血友病的诊断和治疗已取得显著进展，但出血仍对现有治疗方法难以奏效，关节疾病仍然是个问题。物理治疗和疼痛治疗是目前多学科综合治疗血友病患者（PWH）的主要方法。本综述的重点是在新的创新疗法时代保护关节健康：2024 年 2 月 1 日，我们使用作为稿件关键词的 MeSH 大主题词对 PubMed Central 进行了检索。本综述将重点介绍关节出血和关节病的已知和未知情况，包括对疼痛这一相关并发症的见解：本综述将讨论旨在促进残疾人关节健康的治疗干预措施的最新进展，包括药物治疗和促进关节健康的相关策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Hematology HEMATOLOGY-

CiteScore

4.70

自引率

3.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Advanced molecular research techniques have transformed hematology in recent years. With improved understanding of hematologic diseases, we now have the opportunity to research and evaluate new biological therapies, new drugs and drug combinations, new treatment schedules and novel approaches including stem cell transplantation. We can also expect proteomics, molecular genetics and biomarker research to facilitate new diagnostic approaches and the identification of appropriate therapies. Further advances in our knowledge regarding the formation and function of blood cells and blood-forming tissues should ensue, and it will be a major challenge for hematologists to adopt these new paradigms and develop integrated strategies to define the best possible patient care. Expert Review of Hematology (1747-4086) puts these advances in context and explores how they will translate directly into clinical practice.