Early-life manipulation of the serotonergic system exacerbates the harmful effects of sleep deprivation on cognitive functions

IF 1.7 4区医学 Q3 DEVELOPMENTAL BIOLOGY International Journal of Developmental Neuroscience Pub Date : 2024-07-10 DOI:10.1002/jdn.10363

Zahra Mashahadi, Hakimeh Saadati, Safa Ghaheri Fard

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Abstract

Serotonin is a monoamine neurotransmitter that plays a main role in regulating physiological and cognitive functions. Serotonergic system dysfunction is involved in the etiology of various psychiatric and neurological disorders. Therefore, the present study was designed to investigate the effects of early-life serotonin depletion on cognitive disorders caused by sleep deprivation. Serotonin was depleted by para-chlorophenylalanine (PCPA, 100 mg/kg, s.c.) at postnatal days 10–20, followed by sleep deprivation-induced through the multiple platform apparatus for 24 h at PND 60. After the examination of the novel object recognition and passive avoidance memories, the hippocampi and prefrontal cortex were dissected to examine the brain-derived neurotrophic factor (BDNF) mRNA expression by PCR. Our findings showed that postnatal serotonin depletion and sleep deprivation impaired the novel object recognition and passive avoidance memories and changed the BDNF levels. In the same way, the serotonin depletion in early life before sleep deprivation exacerbated the harmful effects of sleep deprivation on cognitive function and BDNF levels. It can be claimed that the serotonergic system plays a main role in the modulation of sleep and cognitive functions.

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早年对血清素能系统的操纵会加剧睡眠不足对认知功能的有害影响。

羟色胺是一种单胺神经递质，在调节生理和认知功能方面发挥着主要作用。血清素能系统功能障碍与各种精神和神经疾病的病因有关。因此，本研究旨在探讨早期血清素耗竭对睡眠不足引起的认知障碍的影响。在出生后第10-20天，通过对氯苯丙氨酸（PCPA，100 mg/kg，s.c.）消耗血清素，然后在出生后第60天通过多平台仪器诱导睡眠剥夺24小时。在检查了新物体识别和被动回避记忆后，解剖海马和前额叶皮层，通过PCR检测脑源性神经营养因子（BDNF）mRNA的表达。我们的研究结果表明，出生后血清素耗竭和睡眠剥夺会损害新物体识别记忆和被动回避记忆，并改变BDNF的水平。同样，在剥夺睡眠前的早期血清素耗竭加剧了睡眠剥夺对认知功能和BDNF水平的有害影响。可以说，血清素能系统在调节睡眠和认知功能方面发挥着主要作用。

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来源期刊

International Journal of Developmental Neuroscience 医学-发育生物学

CiteScore

3.30

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： International Journal of Developmental Neuroscience publishes original research articles and critical review papers on all fundamental and clinical aspects of nervous system development, renewal and regeneration, as well as on the effects of genetic and environmental perturbations of brain development and homeostasis leading to neurodevelopmental disorders and neurological conditions. Studies describing the involvement of stem cells in nervous system maintenance and disease (including brain tumours), stem cell-based approaches for the investigation of neurodegenerative diseases, roles of neuroinflammation in development and disease, and neuroevolution are also encouraged. Investigations using molecular, cellular, physiological, genetic and epigenetic approaches in model systems ranging from simple invertebrates to human iPSC-based 2D and 3D models are encouraged, as are studies using experimental models that provide behavioural or evolutionary insights. The journal also publishes Special Issues dealing with topics at the cutting edge of research edited by Guest Editors appointed by the Editor in Chief. A major aim of the journal is to facilitate the transfer of fundamental studies of nervous system development, maintenance, and disease to clinical applications. The journal thus intends to disseminate valuable information for both biologists and physicians. International Journal of Developmental Neuroscience is owned and supported by The International Society for Developmental Neuroscience (ISDN), an organization of scientists interested in advancing developmental neuroscience research in the broadest sense.