Development and validation of a home quantitative sensory testing tool-kit to assess changes in sensory and pain processing: a study in healthy young adults.

IF 5.9 1区 医学 Q1 ANESTHESIOLOGY PAIN® Pub Date : 2025-01-01 Epub Date: 2024-07-09 DOI:10.1097/j.pain.0000000000003320
Don Daniel Ocay, Kimberly Lobo, Angela Kim, Meghan Halpin, Charles B Berde
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Abstract

Abstract: Quantitative sensory testing (QST) is a set of methods for quantifying somatosensory functioning. Limitations of laboratory-based QST (LQST) include high cost, complexity in training, lack of portability, and time requirements for testing. Translating QST to a home setting could facilitate future research and clinical care. The objective of this study was to develop a home QST (HQST) tool-kit that is cost-effective, easy to use, and detects changes in sensory and pain processing. Thirty-two young healthy adults underwent sensory testing on their nondominant forearm using standard in-person LQST, followed by "simulated HQST" using video guidance in a separate room from the investigator before and after application of either a lidocaine or capsaicin cream. We observed good agreement between HQST and LQST scores, with significant correlations observed between the pinprick, pressure, cold and heat measures (|ρ| range = 0.36-0.54). The participants rated the HQST protocol as highly acceptable and safe but can be improved in future implementations. Home QST was able to detect hypoesthesia to vibration after lidocaine cream application ( P = 0.024, d = 0.502) and could detect hypoalgesia and hyperalgesia to pressure and heat pain sensitivity tests after application of lidocaine and capsaicin creams, respectively ( P -value range = <0.001-0.036, d -value range = 0.563-0.901). Despite limitations, HQST tool-kits may become a cost-effective, convenient, and scalable approach for improving sensory profiling in clinical care and clinical research.

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开发和验证用于评估感觉和疼痛处理变化的家庭定量感觉测试工具包:一项针对健康年轻人的研究。
摘要:定量感觉测试(QST)是一套量化躯体感觉功能的方法。基于实验室的 QST(LQST)的局限性包括成本高、训练复杂、缺乏便携性以及测试时间要求。将 QST 移植到家庭环境可促进未来的研究和临床治疗。本研究的目的是开发一种家庭 QST(HQST)工具包,它成本低廉、易于使用,并能检测感觉和疼痛处理过程的变化。32 名年轻健康的成年人在使用利多卡因或辣椒素药膏前后,使用标准的当面 LQST 对他们的非支配前臂进行了感觉测试,然后在与研究人员分开的房间里使用视频指导进行了 "模拟 HQST"。我们观察到 HQST 和 LQST 分数之间的一致性很好,针刺、压力、冷和热测量之间存在显著相关性(|ρ| 范围 = 0.36-0.54)。参与者对 HQST 方案的评价是高度可接受和安全,但在今后的实施中仍可改进。家用 QST 能够检测出涂抹利多卡因乳膏后对振动的感觉减退(P = 0.024,d = 0.502),并能检测出涂抹利多卡因乳膏和辣椒素乳膏后分别对压力和热痛敏试验的感觉减退和感觉减退(P 值范围 = 0.05-0.05)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
PAIN®
PAIN® 医学-临床神经学
CiteScore
12.50
自引率
8.10%
发文量
242
审稿时长
9 months
期刊介绍: PAIN® is the official publication of the International Association for the Study of Pain and publishes original research on the nature,mechanisms and treatment of pain.PAIN® provides a forum for the dissemination of research in the basic and clinical sciences of multidisciplinary interest.
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