Estimating the prevalence and clinical causality of obstructive sleep apnea in paediatric narcolepsy patients.

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY Sleep and Breathing Pub Date : 2024-10-01 Epub Date: 2024-07-10 DOI:10.1007/s11325-024-03100-6

Chaofan Geng, Chen Chen

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Abstract

Background: Numerous risk factors in paediatric narcolepsy may predispose them to obstructive sleep apnea (OSA). The concurrent presence of OSA in these patients might lead to underdiagnosing narcolepsy. This research investigates the prevalence and potential causality between OSA and paediatric narcolepsy.

Methods: A case-control study coupled with a two-sample Mendelian randomization (MR) analysis was employed to explore the prevalence and causal link between paediatric narcolepsy and OSA risk.

Results: The case-control study revealed that paediatric narcolepsy patients are at an increased risk of OSA, with an Odds ratio (OR) of 4.87 (95% CI: 2.20-10.71; P < 0.001). The inverse-variance weighted (IVW) model further suggests a potential causal link between narcolepsy and OSA (IVW OR: 4.671, 95% CI: 1.925-11.290; P < 0.001). Additionally, sensitivity analysis confirmed these findings' reliability.

Conclusion: The findings highlight an elevated prevalence and genetic susceptibility to OSA among paediatric narcolepsy patients, underscoring the necessity for clinical screening of OSA. Continued research is essential to clarify the pathogenic mechanisms and develop potential treatments.

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估算儿科嗜睡症患者阻塞性睡眠呼吸暂停的患病率和临床因果关系。

背景：小儿嗜睡症的众多风险因素可能导致他们患上阻塞性睡眠呼吸暂停（OSA）。这些患者同时患有 OSA 可能会导致对嗜睡症的诊断不足。本研究调查了 OSA 与儿童嗜睡症之间的患病率和潜在因果关系：方法：采用病例对照研究和双样本孟德尔随机化（MR）分析，探讨小儿嗜睡症与 OSA 风险之间的患病率和因果关系：结果：病例对照研究显示，小儿嗜睡症患者患 OSA 的风险增加，患病率比（OR）为 4.87（95% CI：2.20-10.71；P 结论：研究结果表明，小儿嗜睡症与 OSA 的患病率和因果关系有密切关系：研究结果表明，在儿科嗜睡症患者中，OSA 的患病率和遗传易感性都很高，这突出了对 OSA 进行临床筛查的必要性。继续开展研究对于阐明致病机制和开发潜在治疗方法至关重要。

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来源期刊

Sleep and Breathing 医学-呼吸系统

CiteScore

5.20

自引率

4.00%

发文量

222

审稿时长

3-8 weeks

期刊介绍： The journal Sleep and Breathing aims to reflect the state of the art in the international science and practice of sleep medicine. The journal is based on the recognition that management of sleep disorders requires a multi-disciplinary approach and diverse perspectives. The initial focus of Sleep and Breathing is on timely and original studies that collect, intervene, or otherwise inform all clinicians and scientists in medicine, dentistry and oral surgery, otolaryngology, and epidemiology on the management of the upper airway during sleep. Furthermore, Sleep and Breathing endeavors to bring readers cutting edge information about all evolving aspects of common sleep disorders or disruptions, such as insomnia and shift work. The journal includes not only patient studies, but also studies that emphasize the principles of physiology and pathophysiology or illustrate potentially novel approaches to diagnosis and treatment. In addition, the journal features articles that describe patient-oriented and cost-benefit health outcomes research. Thus, with peer review by an international Editorial Board and prompt English-language publication, Sleep and Breathing provides rapid dissemination of clinical and clinically related scientific information. But it also does more: it is dedicated to making the most important developments in sleep disordered breathing easily accessible to clinicians who are treating sleep apnea by presenting well-chosen, well-written, and highly organized information that is useful for patient care.