Fatma Said, Ines Naceur, Tayssir Ben Achour, Maysam Jeridi, Imed Ben Ghorbel, Monia Smiti
{"title":"Particularities of Sjögren Syndrome in elderly.","authors":"Fatma Said, Ines Naceur, Tayssir Ben Achour, Maysam Jeridi, Imed Ben Ghorbel, Monia Smiti","doi":"10.62438/tunismed.v102i7.4876","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Diagnosis of Sjögren syndrome (SS) can be difficult in the elderly in whom sicca syndrome can be related to senescence, comorbidities or to iatrogenesis.</p><p><strong>Methods: </strong>We performed a retrospective study including of SS patients records (AECG criteria) in the internal medicine departement, La Rabta Hospital over 18 years. Epidemiological, clinical, biological and therapeutic features of elderly patients (EP) and young patients(YP) were compared Results: A total of 323 patients with SS were enrolled, 35 were over 65 years of age (33 females/2 males). The mean age at disease onset was 68.8±4.4 years. Comparative analysis showed that SS diagnosis was made earlier in elderly (p=0.02). Fatigue was more frequent in elderly (p<0.01). Positivity of anti-SSA was more frequent in YP (p=0.04). Anti-malarial agents were less prescribed in elderly (p=0.03). There was no significant differences concerning the other clinical features, laboratory findings, treatment and outcomes.</p><p><strong>Conclusion: </strong>The SS in elderly seems not to be a distinct subset of disease. However, treatment and follow-up of elderly patients with SS must obey to closer attention considering their vulnerability and the complexity of their management.</p>","PeriodicalId":38818,"journal":{"name":"Tunisie Medicale","volume":"102 7","pages":"419-422"},"PeriodicalIF":0.0000,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11358767/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tunisie Medicale","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.62438/tunismed.v102i7.4876","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Diagnosis of Sjögren syndrome (SS) can be difficult in the elderly in whom sicca syndrome can be related to senescence, comorbidities or to iatrogenesis.
Methods: We performed a retrospective study including of SS patients records (AECG criteria) in the internal medicine departement, La Rabta Hospital over 18 years. Epidemiological, clinical, biological and therapeutic features of elderly patients (EP) and young patients(YP) were compared Results: A total of 323 patients with SS were enrolled, 35 were over 65 years of age (33 females/2 males). The mean age at disease onset was 68.8±4.4 years. Comparative analysis showed that SS diagnosis was made earlier in elderly (p=0.02). Fatigue was more frequent in elderly (p<0.01). Positivity of anti-SSA was more frequent in YP (p=0.04). Anti-malarial agents were less prescribed in elderly (p=0.03). There was no significant differences concerning the other clinical features, laboratory findings, treatment and outcomes.
Conclusion: The SS in elderly seems not to be a distinct subset of disease. However, treatment and follow-up of elderly patients with SS must obey to closer attention considering their vulnerability and the complexity of their management.
导言:诊断老年人的斯约格伦综合征(SS)可能很困难,因为老年人的睑板腺综合征可能与衰老、合并症或先天性疾病有关:方法:我们进行了一项回顾性研究,其中包括 La Rabta 医院内科 18 年来的沙格氏综合征患者病历(AECG 标准)。比较了老年患者(EP)和年轻患者(YP)的流行病学、临床、生物学和治疗特征:共有 323 名 SS 患者入选,其中 35 人年龄超过 65 岁(33 名女性/2 名男性)。平均发病年龄为(68.8±4.4)岁。对比分析表明,老年人确诊 SS 的时间更早(P=0.02)。疲劳在老年人中更为常见(P结论:老年人的 SS 似乎不是一种独特的疾病。然而,考虑到老年 SS 患者的易感性和治疗的复杂性,必须对他们的治疗和随访给予更多关注。