Acute effects of apnea bouts on hemoglobin concentration and hematocrit: a systematic review and meta-analysis.

IF 0.7 4区医学 Q4 MARINE & FRESHWATER BIOLOGY Undersea and Hyperbaric Medicine Pub Date : 2024-02-01

Omar López-Rebenaque, Luis Solís-Ferrer, José Fierro-Marrero, Francisco de Asís-Fernández

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Abstract

Objective: This study aimed to systematically analyze the existing literature and conduct a meta-analysis on the acute effects of apnea on the hematological response by assessing changes in hemoglobin (Hb) concentration and hematocrit (Hct) values.

Methods: Searches in Pubmed, The Cochrane Library, and Web of Science were carried out for studies in which the main intervention was voluntary hypoventilation, and Hb and Hct values were measured. Risk of bias and quality assessments were performed.

Results: Nine studies with data from 160 participants were included, involving both subjects experienced in breath-hold sports and physically active subjects unrelated to breath-holding activities. The GRADE scale showed a "high" confidence for Hb concentration, with a mean absolute effect of 0.57 g/dL over control interventions. "Moderate" confidence appeared for Hct, where the mean absolute effect was 2.45% higher over control interventions. Hb concentration increased to a greater extent in the apnea group compared to the control group (MD = 0.57 g/dL [95% CI 0.28, 0.86], Z = 3.81, p = 0.0001) as occurred with Hct (MD = 2.45% [95% CI 0.98, 3.93], Z = 3.26, p = 0.001).

Conclusions: Apnea bouts lead to a significant increase in the concentration of Hb and Hct with a high and moderate quality of evidence, respectively. Further trials on apnea and its application to different settings are needed.

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呼吸暂停对血红蛋白浓度和血细胞比容的急性影响：系统回顾和荟萃分析。

研究目的本研究旨在系统分析现有文献，并通过评估血红蛋白（Hb）浓度和血细胞比容（Hct）值的变化，对呼吸暂停对血液反应的急性影响进行荟萃分析：方法：在 Pubmed、The Cochrane Library 和 Web of Science 中检索以自愿低通气为主要干预措施并测量 Hb 和 Hct 值的研究。进行了偏倚风险和质量评估：结果：共纳入了 9 项研究，160 名参与者参与了研究，研究对象既包括有憋气运动经验的受试者，也包括与憋气活动无关的体力活动受试者。GRADE 量表显示，血红蛋白浓度的可信度为 "高"，与对照干预相比，平均绝对效应为 0.57 g/dL。血红蛋白浓度的可信度为 "中等"，其平均绝对效果比对照组干预措施高出 2.45%。与对照组相比，呼吸暂停组的 Hb 浓度增加幅度更大（MD = 0.57 g/dL [95% CI 0.28, 0.86]，Z = 3.81，p = 0.0001），Hct 也是如此（MD = 2.45% [95% CI 0.98, 3.93]，Z = 3.26，p = 0.001）：呼吸暂停可显著提高血红蛋白和血清白蛋白的浓度，其证据质量分别为高和中等。需要对呼吸暂停及其在不同环境中的应用进行进一步试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Undersea and Hyperbaric Medicine 医学-海洋与淡水生物学

CiteScore

1.60

自引率

11.10%

发文量

审稿时长

>12 weeks

期刊介绍： Undersea and Hyperbaric Medicine Journal accepts manuscripts for publication that are related to the areas of diving research and physiology, hyperbaric medicine and oxygen therapy, submarine medicine, naval medicine and clinical research related to the above topics. To be considered for UHM scientific papers must deal with significant and new research in an area related to biological, physical and clinical phenomena related to the above environments.