Hepatitis E virus infections.

Basavraj S Nagoba, Abhijit S Rayate
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Abstract

Hepatitis E virus (HEV) infection is now endemic worldwide. Most patients with acute infection recover uneventfully. Outbreaks and sporadic cases, particularly in high-risk individuals are emerging increasingly. The patients with risk factors like pregnancy and pre-existing chronic liver disease, present with or progress rapidly to severe disease. Immuno-suppression in post-transplant patients is an additional risk factor. Standardized FDA-approved diagnostic tests are the need of the hour. Further studies are needed to establish guideline-based treatment regimen and outbreak preparedness for HEV to decrease global morbidity, mortality, and healthcare burden. Policies for screening donors and transplant cases are required.

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戊型肝炎病毒感染。
戊型肝炎病毒(HEV)感染目前在全球流行。大多数急性感染患者都能顺利康复。爆发和零星病例,尤其是高危人群中的爆发和零星病例正日益增多。有妊娠和原有慢性肝病等危险因素的患者会出现或迅速发展为重症。移植后患者的免疫抑制也是一个风险因素。当务之急是进行经美国食品及药物管理局批准的标准化诊断检测。需要开展进一步研究,以制定基于指南的治疗方案和 HEV 爆发准备工作,从而降低全球发病率、死亡率和医疗负担。需要制定筛查捐献者和移植病例的政策。
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