Pooja Goyal, Akhil K. Dubey, Raghunath Chowdhury, Amey Wadawale
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引用次数: 0
Abstract
The enantioselective 1,4-addition reaction of pyrazolin-5-ones to α,β-unsaturated ketones catalyzed by a cinchona alkaloid-derived primary amine–Brønsted acid composite is reported. Both enantiomers of the anticipated pyrazole derivatives were obtained in good to excellent yields (up to 97%) and high enantioselectivities (up to 98.5% ee) under mild reaction conditions. In addition, this protocol was further expanded to synthesize highly enantioenriched hybrid molecules bearing biologically relevant heterocycles.
Beilstein J. Org. Chem.2024,20, 1518–1526. doi:10.3762/bjoc.20.136
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