E. G. Korzhikova-Vlakh, A. Yu. Dzhuzha, V. D. Matvienko, G. A. Platonova, T. B. Tennikova
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引用次数: 0
Abstract
Amphiphilic copolymers of amino acids capable of self-assembly in aqueous media into nanoparticles are of interest as potential drug delivery systems. In this work, a series of amphiphilic copolymers of lysine and phenylalanine with different chirality and content of monomer units are synthesized and characterized. Effect of the composition of copolymers on the characteristics and physicochemical and biological properties of nanoparticles formed due to self-assembly is studied. Specifically, the hydrodynamic characteristics of nanoparticles are determined and compared with average diameters in the dry state. Critical aggregation concentrations are assessed and effect of the рН of medium and the time of incubation on the stability of dispersions of nanoparticles is investigated. In addition, the data on the cytotoxicity of nanosystems depending on the chirality of hydrophobic amino acid are obtained.
期刊介绍：
Polymer Science, Series A is a journal published in collaboration with the Russian Academy of Sciences. Series A includes experimental and theoretical papers and reviews devoted to physicochemical studies of the structure and properties of polymers (6 issues a year). All journal series present original papers and reviews covering all fundamental aspects of macromolecular science. Contributions should be of marked novelty and interest for a broad readership. Articles may be written in English or Russian regardless of country and nationality of authors. All manuscripts are peer reviewed. Online submission via Internet to the Series A, B, and C is available at http://polymsci.ru.
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