Characterization of Radiochromic Hydrogel Dosimeter-Ferrous Xylenol Orange Enhanced to Have a Higher Melting Point

IF 1.5 4区 物理与天体物理 Q2 PHYSICS, MULTIDISCIPLINARY Brazilian Journal of Physics Pub Date : 2024-07-09 DOI:10.1007/s13538-024-01521-y
Matheus Antonio da Silveira, Juliana Fernandes Pavoni, Kevin Jordan, Oswaldo Baffa
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Abstract

Ferrous xylenol orange (FXO) radiochromic gelatin gel dosimeter has the potential to provide tridimensional dosimetry for the assessment of new technologies of treatment in radiotherapy. However, one problem with the present formulations of these gels is the low melting point of the gelatin matrix. To solve this problem, formaldehyde was added to this gel dosimeter to promote crosslinking in the gelatin matrix, thus increasing the melting point. Five different formulations of FXO gel were tested, the best melting point temperature found was 62 °C or higher, and the 0.210 mm2/hr of diffusion rate was obtained on the 8% gelatin with 3% formaldehyde, 75% lower than original formulation. To provide clinical uses of these dosimeters, this work deals with the dosimetric characterization of modified FXO. No energy dependence was found when irradiated with 6 MV and 15 MV beams; also, no dose rate dependence was found varying low to high dose rate, 100 to 1400 cGy/min. These characteristics allow this dosimeter to useful for clinical context.

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放射性变色水凝胶剂量计的特性--增强的亚铁二甲酚橙具有更高的熔点
亚铁二甲酚橙(FXO)放射性变色明胶凝胶剂量计具有提供三维剂量测定的潜力,可用于放射治疗新技术的评估。然而,目前这些凝胶配方的一个问题是明胶基质的熔点较低。为了解决这个问题,在这种凝胶剂量计中加入了甲醛,以促进明胶基质的交联,从而提高熔点。对五种不同配方的 FXO 凝胶进行了测试,发现最佳熔点温度为 62 ℃ 或更高,添加 3% 甲醛的 8% 明胶的扩散率为 0.210 mm2/hr,比原始配方低 75%。为了将这些剂量计用于临床,本研究对改性 FXO 进行了剂量学表征。在用 6 MV 和 15 MV 射束照射时,没有发现能量依赖性;从低到高剂量率(100 到 1400 cGy/min)的变化中,也没有发现剂量率依赖性。这些特点使得这种剂量计在临床上大有用武之地。
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来源期刊
Brazilian Journal of Physics
Brazilian Journal of Physics 物理-物理:综合
CiteScore
2.50
自引率
6.20%
发文量
189
审稿时长
6.0 months
期刊介绍: The Brazilian Journal of Physics is a peer-reviewed international journal published by the Brazilian Physical Society (SBF). The journal publishes new and original research results from all areas of physics, obtained in Brazil and from anywhere else in the world. Contents include theoretical, practical and experimental papers as well as high-quality review papers. Submissions should follow the generally accepted structure for journal articles with basic elements: title, abstract, introduction, results, conclusions, and references.
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