{"title":"Mechanisms of Mycobacterium tuberculosis Drug Resistance","authors":"M. V. Shulgina","doi":"10.3103/s0891416824700010","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>The review presents the results of investigations of the mechanisms of action of long-used and new antituberculosis drugs, and information about new chemical compounds as potential antituberculosis drugs. Data are given on mutations in a number of infectant genes associated with or leading to bacterial resistance to these drugs. The review comprises the results of 67 publications, systematic reviews, and electronic databases.</p>","PeriodicalId":19005,"journal":{"name":"Molecular Genetics, Microbiology and Virology","volume":"149 1","pages":""},"PeriodicalIF":0.4000,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Genetics, Microbiology and Virology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.3103/s0891416824700010","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The review presents the results of investigations of the mechanisms of action of long-used and new antituberculosis drugs, and information about new chemical compounds as potential antituberculosis drugs. Data are given on mutations in a number of infectant genes associated with or leading to bacterial resistance to these drugs. The review comprises the results of 67 publications, systematic reviews, and electronic databases.
期刊介绍：
Molecular Genetics, Microbiology and Virology is a journal that covers most topical theoretical and applied problems of molecular genetics of pro- and eukaryotic organisms, molecular microbiology and molecular virology. An important part the journal assigns to investigations of the genetic apparatus of microorganisms, searching for forms of genetic exchange, genetic mapping of pathogenic causative agents, to ascertainment of the structure and functions of extrachromosomal factors of heredity and migratory genetic elements, to theoretical studies into the mechanisms of genetic regulation. The journal publishes results of research on molecular and genetic bases of an eukaryotic cell, functioning of chromosomes and chromatin, nature of genetic changes in malignization and a set of hereditary diseases. On the pages of the journal there is covered the formulation of molecular bases of virology including issues of integration of viral and cellular genomes, and issues of persistence. The journal plans to put materials on genetic engineering, envisaging synthesis and isolation of genes from natural reservoirs, creation of plasmid- and virus-based vector, production of recombinant DNA molecules, the creation of Gene Banks for Microbes, animals, and human; and also on biotechnological production of hormones, components of antiviral vaccines, diagnostic and therapeutic preparations.
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