Mechanisms of resistance to trastuzumab in HER2-positive gastric cancer.

IF 7 2区 医学 Q1 ONCOLOGY Chinese Journal of Cancer Research Pub Date : 2024-06-30 DOI:10.21147/j.issn.1000-9604.2024.03.07
Zhifei Li, Huan Zhao, Huihui Hu, Haili Shang, Yongjing Ren, Wenhui Qiu, Hao Su, Huifang Lyu, Xiaobing Chen
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Abstract

Gastric cancer is one of the most prevalent cancers worldwide, and human epidermal growth factor receptor 2 (HER2)-positive cases account for approximately 20% of the total cases. Currently, trastuzumab + chemotherapy is the recommended first-line treatment for patients with HER2-positive advanced gastric cancer, and the combination has exhibited definite efficacy in HER2-targeted therapy. However, the emergence of drug resistance during treatment considerably reduces its effectiveness; thus, it is imperative to investigate the potential mechanisms underlying resistance. In the present review article, we comprehensively introduce multiple mechanisms underlying resistance to trastuzumab in HER2-positive gastric cancer cases, aiming to provide insights for rectifying issues associated with resistance to trastuzumab and devising subsequent treatment strategies.

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HER2阳性胃癌对曲妥珠单抗耐药的机制。
胃癌是全球发病率最高的癌症之一,人表皮生长因子受体 2(HER2)阳性病例约占总病例的 20%。目前,曲妥珠单抗+化疗是HER2阳性晚期胃癌患者的推荐一线治疗方案,这种联合疗法在HER2靶向治疗中表现出了确切的疗效。然而,治疗过程中耐药性的出现大大降低了治疗效果;因此,研究耐药性的潜在机制势在必行。在本综述文章中,我们全面介绍了HER2阳性胃癌病例对曲妥珠单抗耐药的多种机制,旨在为纠正曲妥珠单抗耐药相关问题和制定后续治疗策略提供启示。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
自引率
9.80%
发文量
1726
审稿时长
4.5 months
期刊介绍: Chinese Journal of Cancer Research (CJCR; Print ISSN: 1000-9604; Online ISSN:1993-0631) is published by AME Publishing Company in association with Chinese Anti-Cancer Association.It was launched in March 1995 as a quarterly publication and is now published bi-monthly since February 2013. CJCR is published bi-monthly in English, and is an international journal devoted to the life sciences and medical sciences. It publishes peer-reviewed original articles of basic investigations and clinical observations, reviews and brief communications providing a forum for the recent experimental and clinical advances in cancer research. This journal is indexed in Science Citation Index Expanded (SCIE), PubMed/PubMed Central (PMC), Scopus, SciSearch, Chemistry Abstracts (CA), the Excerpta Medica/EMBASE, Chinainfo, CNKI, CSCI, etc.
期刊最新文献
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