Progress towards permanent respiratory support.

IF 1.8 4区 医学 Q3 TRANSPLANTATION Current Opinion in Organ Transplantation Pub Date : 2024-10-01 Epub Date: 2024-07-10 DOI:10.1097/MOT.0000000000001163
Suji Shin, Umar Nasim, Hassana O'Connor, Yeahwa Hong
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Abstract

Purpose of review: Although lung transplantation stands as the gold standard curative therapy option for end-stage lung disease, the scarcity of available organs poses a significant challenge in meeting the escalating demand. This review provides an overview of recent advancements in ambulatory respiratory assist systems, selective anticoagulation therapies that target the intrinsic pathway, and innovative surface coatings to enable permanent respiratory support as a viable alternative to lung transplantation.

Recent findings: Several emerging ambulatory respiratory assist systems have shown promise in both preclinical and clinical trials. These systems aim to create more biocompatible, compact, and portable forms of extracorporeal membrane oxygenation that can provide long-term respiratory support. Additionally, innovative selective anticoagulation strategies, currently in various stages of preclinical or clinical development, present a promising alternative to currently utilized nonselective anticoagulants. Moreover, novel surface coatings hold the potential to locally prevent artificial surface-induced thrombosis and minimize bleeding risks.

Summary: This review of recent advancements toward permanent respiratory support summarizes the development of ambulatory respiratory assist systems, selective anticoagulation therapies, and novel surface coatings. The integration of these evolving device technologies with targeted anticoagulation strategies may allow a safe and effective mode of permanent respiratory support for patients with chronic lung disease.

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在实现永久性呼吸支持方面取得进展。
回顾的目的:尽管肺移植是治疗终末期肺病的金标准疗法,但可用器官的稀缺给满足不断增长的需求带来了巨大挑战。本综述概述了非卧床呼吸辅助系统、针对内在通路的选择性抗凝疗法和创新性表面涂层的最新进展,以实现永久性呼吸支持,作为肺移植的可行替代方案:一些新兴的流动呼吸辅助系统已在临床前和临床试验中显示出前景。这些系统旨在创造生物相容性更好、结构更紧凑、更便携的体外膜氧合形式,以提供长期呼吸支持。此外,创新的选择性抗凝策略目前正处于不同的临床前或临床开发阶段,有望替代目前使用的非选择性抗凝剂。此外,新型表面涂层有可能在局部预防人工表面诱发的血栓形成,并将出血风险降至最低。摘要:本文回顾了永久性呼吸支持的最新进展,总结了非卧床呼吸辅助系统、选择性抗凝疗法和新型表面涂层的发展情况。将这些不断发展的设备技术与有针对性的抗凝策略相结合,可为慢性肺病患者提供一种安全有效的永久性呼吸支持模式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.10
自引率
4.50%
发文量
124
审稿时长
6-12 weeks
期刊介绍: ​​​​​​Current Opinion in Organ Transplantation is an indispensable resource featuring key, up-to-date and important advances in the field from around the world. Led by renowned guest editors for each section, every bimonthly issue of Current Opinion in Organ Transplantation delivers a fresh insight into topics such as stem cell transplantation, immunosuppression, tolerance induction and organ preservation and procurement. With 18 sections in total, the journal provides a convenient and thorough review of the field and will be of interest to researchers, surgeons and other healthcare professionals alike.
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