Primary cutaneous EBV+ extranodal NK/T-cell lymphoma of gamma/delta T-cell lineage in the posttransplantation setting

IF 1.6 4区 医学 Q3 DERMATOLOGY Journal of Cutaneous Pathology Pub Date : 2024-07-10 DOI:10.1111/cup.14677
Jessica F. Williams, Fabienne M. Lucas, Ruben D. Carrasco, Scott B. Lovitch, David C. Fisher, Thomas S. Kupper, Sam Sadigh
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Abstract

Posttransplantation primary cutaneous T-cell lymphomas (PT-CTCL) are a rare complication of sustained immunosuppression in the posttransplant setting. When present, PT-CTCLs are typically EBV− and exhibit features of mycosis fungoides/Sézary syndrome or CD30+ lymphoproliferative disorders. We present a case of a 75-year-old individual who developed skin lesions 30 years after liver transplantation. Pathologic evaluation of the skin biopsy revealed involvement by a clonal, EBV+ T-cell population of gamma/delta lineage with no evidence of systemic disease. Comprehensive genomic profiling was performed, confirming focal one-copy loss of 6q23.3, altogether consistent with the extremely rare and unusual diagnosis of primary cutaneous EBV+ extranodal NK/T-cell lymphoma of gamma/delta T-cell lineage in the posttransplantation setting.

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移植后皮肤原发性EBV+结节外γ/δT细胞系NK/T细胞淋巴瘤。
移植后原发性皮肤T细胞淋巴瘤(PT-CTCL)是移植后持续免疫抑制的一种罕见并发症。PT-CTCL通常与EB病毒有关,并具有真菌病/塞扎里综合征或CD30+淋巴增生性疾病的特征。我们报告了一例 75 岁的患者,他在接受肝移植手术 30 年后出现皮肤病变。对皮肤活检的病理评估显示,γ/δ系的克隆、EBV+ T细胞群受累,但没有全身性疾病的证据。综合基因组图谱检查证实了 6q23.3 局灶性单拷贝缺失,这与原发性皮肤 EBV+结节外 NK/T 细胞淋巴瘤(γ/delta T 细胞系)这一极其罕见和不寻常的诊断一致。
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来源期刊
CiteScore
3.20
自引率
5.90%
发文量
174
审稿时长
3-8 weeks
期刊介绍: Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.
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