Doxycycline pharmacokinetics and tissue depletion in striped catfish (Pagasianodon hypophthalmus) after oral administration.

IF 1.5 4区 农林科学 Q3 PHARMACOLOGY & PHARMACY Journal of veterinary pharmacology and therapeutics Pub Date : 2024-07-10 DOI:10.1111/jvp.13471
Pham Quang Vinh, Nguyen Quoc Thinh, Mathias Devreese, Siska Croubels, Dang Thi Hoang Oanh, Anders Dalsgaard, Masashi Maita, Tran Minh Phu
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Abstract

The pharmacokinetics and residue depletion of doxycycline (DOX) in striped catfish (Pagasianodon hypophthalmus) after oral dosage were investigated. The pharmacokinetic experiment was conducted in an aquarium, while the experiment of residue depletion was performed in both an aquarium and earth ponds. Medicated feed was administered orally using the gavage method at a dosage of 20 mg/kg body weight. Blood, liver, and kidney from medicated fish samples were collected. In the depletion experiments, fish were fed medicated feed for five consecutive days at a dosage of 20 mg/kg body weight, with samples collected during and after medication. The concentrations of DOX were quantified using an LC-MS/MS system. The pharmacokinetics parameters of DOX in striped catfish included the absorption rate constant (ka), absorption half-life (T1/2abs), maximal plasma concentration (Cmax), time to maximal plasma concentration (Tmax), and area under the plasma concentration-time curve from time 0 to 96 h (AUC0-96 h) which were 0.12 h-1, 5.68 h, 1123.45 ng/mL, 8.19 h, and 25,018 ng/mL/h, respectively. Residue depletion results indicated that the withdrawal times of DOX in muscle (with skin) from fish kept in the aquarium were slightly longer than that in fish raised in earth ponds, corresponding to 194 degree-days compared with 150 degree-days. In conclusion, administration of DOX at the dosage of 20 mg/kg body weight can be used for treatment of bacterial infections in striped catfish, and a withdrawal time of 5 days at 29.4°C will ensure consumer food safety due to the rapid depletion of DOX from muscle and skin.

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口服多西环素后带鱼的药代动力学和组织损耗。
研究了多西环素(DOX)在带鱼(Pagasianodon hypophthalmus)口服后的药代动力学和残留消耗。药代动力学实验在水族箱中进行,而残留物消耗实验则在水族箱和土池中进行。采用灌胃法口服给药饲料,剂量为 20 毫克/千克体重。收集用药鱼的血液、肝脏和肾脏样本。在耗竭实验中,以每公斤体重 20 毫克的剂量给鱼连续喂食五天药物饲料,并在用药期间和用药后采集样本。使用 LC-MS/MS 系统对 DOX 的浓度进行定量。DOX在带鱼体内的药代动力学参数包括吸收率常数(ka)、吸收半衰期(T1/2abs)、最大血浆浓度(Cmax)、达到最大血浆浓度的时间(Tmax)和从0到96小时的血浆浓度-时间曲线下面积(AUC0-96 h),分别为0.12 h-1、5.68 h、1123.45 ng/mL、8.19 h和25 018 ng/mL/h。残留消耗结果表明,水族箱养鱼肌肉(连皮)中 DOX 的撤出时间略长于土塘养鱼,分别为 194 度日和 150 度日。总之,以每公斤体重 20 毫克的剂量服用 DOX 可用于治疗带鱼的细菌感染,由于肌肉和皮肤中 DOX 的快速消耗,29.4°C 下 5 天的停药时间可确保消费者的食品安全。
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来源期刊
CiteScore
3.10
自引率
15.40%
发文量
69
审稿时长
8-16 weeks
期刊介绍: The Journal of Veterinary Pharmacology and Therapeutics (JVPT) is an international journal devoted to the publication of scientific papers in the basic and clinical aspects of veterinary pharmacology and toxicology, whether the study is in vitro, in vivo, ex vivo or in silico. The Journal is a forum for recent scientific information and developments in the discipline of veterinary pharmacology, including toxicology and therapeutics. Studies that are entirely in vitro will not be considered within the scope of JVPT unless the study has direct relevance to the use of the drug (including toxicants and feed additives) in veterinary species, or that it can be clearly demonstrated that a similar outcome would be expected in vivo. These studies should consider approved or widely used veterinary drugs and/or drugs with broad applicability to veterinary species.
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