Hemodynamic Characteristics of a Tortuous Microvessel Using High-Fidelity Red Blood Cell Resolved Simulations

IF 1.9 4区医学 Q3 HEMATOLOGY Microcirculation Pub Date : 2024-07-11 DOI:10.1111/micc.12875

Mir Md Nasim Hossain, Nien-Wen Hu, Ali Kazempour, Walter L. Murfee, Peter Balogh

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Abstract

Objective

Tortuous microvessels are characteristic of microvascular remodeling associated with numerous physiological and pathological scenarios. Three-dimensional (3D) hemodynamics in tortuous microvessels influenced by red blood cells (RBCs), however, are largely unknown, and important questions remain. Is blood viscosity influenced by vessel tortuosity? How do RBC dynamics affect wall shear stress (WSS) patterns and the near-wall cell-free layer (CFL) over a range of conditions? The objective of this work was to parameterize hemodynamic characteristics unique to a tortuous microvessel.

Methods

RBC-resolved simulations were performed using an immersed boundary method-based 3D fluid dynamics solver. A representative tortuous microvessel was selected from a stimulated angiogenic network obtained from imaging of the rat mesentery and digitally reconstructed for the simulations. The representative microvessel was a venule with a diameter of approximately 20 μm. The model assumes a constant diameter along the vessel length and does not consider variations due to endothelial cell shapes or the endothelial surface layer.

Results

Microvessel tortuosity was observed to increase blood apparent viscosity compared to a straight tube by up to 26%. WSS spatial variations in high curvature regions reached 23.6 dyne/cm² over the vessel cross-section. The magnitudes of WSS and CFL thickness variations due to tortuosity were strongly influenced by shear rate and negligibly influenced by tube hematocrit levels.

Conclusions

New findings from this work reveal unique tortuosity-dependent hemodynamic characteristics over a range of conditions. The results provide new thought-provoking information to better understand the contribution of tortuous vessels in physiological and pathological processes and help improve reduced-order models.

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利用高保真红细胞分辨模拟分析曲折微血管的血流动力学特征。

目的：迂曲微血管是与多种生理和病理情况相关的微血管重塑的特征。然而，受红细胞（RBC）影响的迂曲微血管中的三维（3D）血液动力学在很大程度上是未知的，而且仍然存在一些重要问题。血液粘度是否受血管迂曲度的影响？在一系列条件下，红细胞动力学如何影响管壁剪切应力（WSS）模式和近壁无细胞层（CFL）？这项工作的目的是对迂曲微血管特有的血液动力学特征进行参数化：方法：使用基于沉浸边界法的三维流体动力学求解器进行了红细胞分辨模拟。从大鼠肠系膜成像获得的受刺激血管生成网络中选取了一条具有代表性的迂曲微血管，并对其进行了数字重建以进行模拟。代表性微血管是直径约为 20 μm 的静脉。该模型假定沿血管长度方向的直径不变，不考虑内皮细胞形状或内皮表层的变化：结果：与直管相比，观察到微血管迂曲会增加血液表观粘度达 26%。高曲率区域的 WSS 空间变化在血管横截面上达到 23.6 达因/平方厘米。迂曲导致的 WSS 和 CFL 厚度变化幅度受剪切率的影响很大，而试管血细胞比容水平的影响可以忽略不计：结论：这项研究的新发现揭示了在一系列条件下迂曲度依赖性血液动力学特征。这些结果为更好地理解迂曲血管在生理和病理过程中的作用提供了新的发人深省的信息，并有助于改进降阶模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microcirculation 医学-外周血管病

CiteScore

5.00

自引率

4.20%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal features original contributions that are the result of investigations contributing significant new information relating to the vascular and lymphatic microcirculation addressed at the intact animal, organ, cellular, or molecular level. Papers describe applications of the methods of physiology, biophysics, bioengineering, genetics, cell biology, biochemistry, and molecular biology to problems in microcirculation. Microcirculation also publishes state-of-the-art reviews that address frontier areas or new advances in technology in the fields of microcirculatory disease and function. Specific areas of interest include: Angiogenesis, growth and remodeling; Transport and exchange of gasses and solutes; Rheology and biorheology; Endothelial cell biology and metabolism; Interactions between endothelium, smooth muscle, parenchymal cells, leukocytes and platelets; Regulation of vasomotor tone; and Microvascular structures, imaging and morphometry. Papers also describe innovations in experimental techniques and instrumentation for studying all aspects of microcirculatory structure and function.

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