Theobromine for Remineralization of White Spot Lesions on Dental Enamel: A Systematic Review and Meta-analysis.

IF 1.4 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Operative dentistry Pub Date : 2024-07-01 DOI:10.2341/23-153-LIT

Arj da Silva, Ri Dos Santos Gonçalves, Mhc de Vasconcelos Catão

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Abstract

Aim: This systematic review and meta-analysis evaluated theobromine's (Theobroma cacao) potential in remineralizing white spot lesions in dental enamel. Methods: This study is reported according to the PRISMA checklist and was registered in PROSPERO (CRD42023414371). In vitro tests that evaluated the remineralizing potential of theobromine compared to fluoride ion after demineralization for the formation of white spot lesions on enamel were selected, with no limitation on the year of publication. Electronic searches were performed in PubMed/MEDLINE, Scopus, and Web of Science by two independent researchers. Thirty articles were received of which six were selected according to the inclusion criteria.

Results: The selected studies evaluated the Enamel Surface Microhardness (SMH), Vickers or Knoop, before and after treatment with theobromine and fluoride solutions. For the SMH Vickers, there were no differences between groups at baseline (p=1.00; mean difference: -0.00; CI: -11.36 to 11.36) and after treatment (p=0.51; mean difference: 4.12; CI: -8.16 to 16.41). The results of SMH Knoop showed differences between groups at baseline, favoring the experimental group (p=0.002; mean difference: 9.84; CI: 3.65 to 16.02) and after treatment favoring the control group (p=0.00001; mean difference: -5.45; CI: -7.62 to -3.27).

Conclusion: The use of theobromine increases the microhardness of dental enamel subjected to a demineralization process, thus being effective in the remineralization of this tissue with success equivalent to that obtained with the use of fluoride.

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用于牙釉质白斑再矿化的可可碱：系统回顾与元分析》。

目的：本系统综述和荟萃分析评估了可可碱（可可碱）在再矿化牙釉质白斑病变方面的潜力。研究方法本研究按照 PRISMA 核对表进行报告，并在 PROSPERO（CRD42023414371）上进行了注册。选取了评估可可碱与氟离子在牙釉质脱矿后形成白斑病变时的再矿化潜力的体外试验，发表年份不限。两位独立研究人员在 PubMed/MEDLINE、Scopus 和 Web of Science 上进行了电子检索。共收到 30 篇文章，根据纳入标准选出其中 6 篇：所选研究对使用可可碱和氟化物溶液治疗前后的牙釉质表面显微硬度（SMH）、维氏或努氏进行了评估。就 SMH 维氏硬度而言，基线（p=1.00；平均差异：-0.00；CI：-11.36 至 11.36）和治疗后（p=0.51；平均差异：4.12；CI：-8.16 至 16.41）两组间无差异。SMH Knoop 的结果显示，基线时各组之间存在差异，实验组更有利（P=0.002；平均差异：9.84；CI：3.65 至 16.02），治疗后对照组更有利（P=0.00001；平均差异：-5.45；CI：-7.62 至 -3.27）：使用可可碱可提高脱矿过程中牙釉质的微硬度，从而有效地使牙釉质组织再矿化，其成功率与使用氟化物相当。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Operative dentistry 医学-牙科与口腔外科

CiteScore

4.00

自引率

9.10%

发文量

124

审稿时长

6-12 weeks

期刊介绍： Operative Dentistry is a refereed, international journal published bi-monthly and distributed to subscribers in over 50 countries. In 2012, we printed 84 articles (672 pages). Papers were submitted by authors from 45 countries, in the categories of Clinical Research, Laboratory Research, Clinical Techniques/Case Presentations and Invited Papers, as well as Editorials and Abstracts. One of the strong points of our journal is that our current publication time for accepted manuscripts is 4 to 6 months from the date of submission. Clinical Techniques/Case Presentations have a very quick turnaround time, which allows for very rapid publication of clinical based concepts. We also provide color for those papers that would benefit from its use. The journal does not accept any advertising but you will find postings for faculty positions. Additionally, the journal also does not rent, sell or otherwise allow its subscriber list to be used by any other entity