Mechanochemical synthesis of β-cyclodextrin urea derivatives under reactive CO2 atmosphere by Staudinger aza-Wittig reaction†

Sawssen Nasri, Maxime Lestoquoy, Anne Ponchel, Eric Monflier and Stéphane Menuel
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Abstract

Various ureido β-cyclodextrins can be easily synthesised by mechanochemistry from azido-β-cyclodextrins, carbon dioxide and amino derivatives. The reaction was carried out with short reaction times, without solvents and without thermal activation, greatly reducing the environmental impact of the synthesis.

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在活性 CO2 气氛下通过 Staudinger aza-Wittig 反应机械化学合成 β-环糊精脲衍生物†。
以叠氮-β-环糊精、二氧化碳和氨基衍生物为原料,通过机械化学反应可轻松合成各种脲基 β-环糊精。该反应无需溶剂和热活化,反应时间短,大大降低了合成对环境的影响。
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