One-year choroidal thickness changes after photodynamic therapy for central serous chorioretinopathy evaluated by widefield optical coherence tomography.

IF 2.4 3区 医学 Q2 OPHTHALMOLOGY Graefe’s Archive for Clinical and Experimental Ophthalmology Pub Date : 2024-12-01 Epub Date: 2024-07-12 DOI:10.1007/s00417-024-06578-8
Shota Sawaguchi, Nobuhiro Terao, Naoya Imanaga, Sorako Wakugawa, Yasunori Miyara, Ayano Oshiro, Marina Maehira, Yukihide Yamauchi, Hideki Koizumi
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Abstract

Purpose: To evaluate the changes in choroidal thickness 1 year after half-dose photodynamic therapy (PDT) for central serous chorioretinopathy (CSC) using widefield swept-source optical coherence tomography.

Methods: We retrospectively reviewed 21 patients with CSC who unilaterally underwent half-dose PDT and completed a 12-month follow-up. Choroidal thickness was evaluated before and after PDT within an 18-mm circular grid centered on the fovea subdivided into nine areas in the treated and untreated fellow eyes.

Results: All 21 treated eyes showed complete resolution of subretinal fluid at 3 months after PDT, without any recurrence at 12 months. The mean choroidal thickness in all nine areas significantly decreased after PDT at 3 months (P < 0.05) and remained unchanged at 12 months (P < 0.05) compared with that at baseline. However, the subtracted choroidal thickness maps between 3 and 12 months detected significant variations among the cases, classified into an enhanced pattern in 10 eyes (47.6%), an attenuated pattern in six eyes (28.6%), and a stable pattern in five eyes (23.8%). The 21 untreated fellow eyes also showed a decrease in mean choroidal thickness in three of the nine subdivided areas at 12 months (P < 0.05), but this decrease was limited posteriorly.

Conclusion: The reduction in mean choroidal thickness after half-dose PDT for CSC was extensively maintained for 1 year. However, subclinical hemodynamic changes in the entire choroid occurred longitudinally even in the absence of disease recurrence.

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通过宽视场光学相干断层扫描评估中心性浆液性脉络膜视网膜病变光动力疗法后一年脉络膜厚度的变化。
目的:使用宽场扫源光学相干断层扫描评估中心性浆液性脉络膜视网膜病变(CSC)半剂量光动力疗法(PDT)1年后脉络膜厚度的变化:我们对 21 例单侧接受半剂量光动力疗法并完成 12 个月随访的 CSC 患者进行了回顾性研究。在以眼窝为中心、细分为九个区域的 18 毫米圆形网格内,对治疗前后的脉络膜厚度进行了评估:结果:所有21只接受治疗的眼睛在PDT治疗3个月后视网膜下积液完全消退,12个月后无任何复发。PDT治疗后3个月,所有9个区域的平均脉络膜厚度均明显降低(P 结论:PDT治疗后3个月,所有9个区域的平均脉络膜厚度均明显降低:半剂量 PDT 治疗 CSC 后,脉络膜平均厚度的减少在 1 年内得到了广泛的维持。然而,即使在疾病没有复发的情况下,整个脉络膜的亚临床血液动力学变化也会纵向发生。
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来源期刊
CiteScore
5.40
自引率
7.40%
发文量
398
审稿时长
3 months
期刊介绍: Graefe''s Archive for Clinical and Experimental Ophthalmology is a distinguished international journal that presents original clinical reports and clini-cally relevant experimental studies. Founded in 1854 by Albrecht von Graefe to serve as a source of useful clinical information and a stimulus for discussion, the journal has published articles by leading ophthalmologists and vision research scientists for more than a century. With peer review by an international Editorial Board and prompt English-language publication, Graefe''s Archive provides rapid dissemination of clinical and clinically related experimental information.
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