Therapeutic potential of exercise-hormone irisin in Alzheimer's disease.

IF 5.9 2区 医学 Q2 CELL BIOLOGY Neural Regeneration Research Pub Date : 2025-06-01 Epub Date: 2024-07-10 DOI:10.4103/NRR.NRR-D-24-00098
Eunhee Kim, Rudolph E Tanzi, Se Hoon Choi
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Abstract

Irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type III domain-containing protein 5 (FNDC5) in response to physical exercise. Studies reveal that irisin/FNDC5 has neuroprotective functions against Alzheimer's disease, the most common form of dementia in the elderly, by improving cognitive function and reducing amyloid-β and tau pathologies as well as neuroinflammation in cell culture or animal models of Alzheimer's disease. Although current and ongoing studies on irisin/FNDC5 show promising results, further mechanistic studies are required to clarify its potential as a meaningful therapeutic target for alleviating Alzheimer's disease. We recently found that irisin treatment reduces amyloid-β pathology by increasing the activity/levels of amyloid-β-degrading enzyme neprilysin secreted from astrocytes. Herein, we present an overview of irisin/FNDC5's protective roles and mechanisms against Alzheimer's disease.

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运动激素鸢尾素对阿尔茨海默病的治疗潜力。
摘要:鸢尾素是一种肌动素,由膜蛋白纤连蛋白Ⅲ型结构域含蛋白5(FNDC5)在体育锻炼时裂解生成。研究表明,鸢尾素/FNDC5 对阿尔茨海默病(老年人最常见的痴呆症)具有神经保护功能,在阿尔茨海默病的细胞培养或动物模型中,鸢尾素/FNDC5 可改善认知功能,减少淀粉样蛋白-β 和 tau 病变以及神经炎症。尽管目前和正在进行的有关鸢尾素/FNDC5的研究显示出了良好的效果,但仍需要进一步的机理研究来阐明其作为缓解阿尔茨海默病的有意义的治疗靶点的潜力。我们最近发现,鸢尾素治疗可通过提高星形胶质细胞分泌的淀粉样蛋白-β降解酶neprilysin的活性/水平来减少淀粉样蛋白-β的病理变化。在此,我们概述了鸢尾素/FNDC5对阿尔茨海默病的保护作用和机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Neural Regeneration Research
Neural Regeneration Research CELL BIOLOGY-NEUROSCIENCES
CiteScore
8.00
自引率
9.80%
发文量
515
审稿时长
1.0 months
期刊介绍: Neural Regeneration Research (NRR) is the Open Access journal specializing in neural regeneration and indexed by SCI-E and PubMed. The journal is committed to publishing articles on basic pathobiology of injury, repair and protection to the nervous system, while considering preclinical and clinical trials targeted at improving traumatically injuried patients and patients with neurodegenerative diseases.
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