Acetyl-11-Keto-β-Boswellic Acid and Incensole Acetate Attenuate Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting Inflammation and Oxidative Stress.

IF 0.5 Q4 UROLOGY & NEPHROLOGY Saudi Journal of Kidney Diseases and Transplantation Pub Date : 2023-12-01 Epub Date: 2024-07-03 DOI:10.4103/sjkdt.sjkdt_41_22

Mohammad Rahim Sharifi, Zhara Hakimi, Mohammad Hosein Eshaghi Ghalibaf, Elham Fazeli, Farimah Behshti, Narges Marefati, Mahmoud Hosseini

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Abstract

Boswellia serrata has been used in traditional medicine to treat various inflammatory diseases. Acetyl-11-keto-β-boswellic acid (AKBA) and incensole acetate (IA) are two active ingredients of B. serrata that possess anti-inflammatory and antioxidant activities. The present study aimed to investigate the protective effects of AKBA and IA against lipopolysaccharide (LPS)- induced acute kidney injury (AKI) in rats. Wistar rats were intraperitoneally pretreated with AKBA or IA for 2 weeks. After 30 min, an LPS injection was applied to induce AKI. Blood samples and kidney tissues were collected and used for biochemical assays. AKBA and IA not only significantly decreased interleukin-6 as a marker of renal inflammation but also attenuated the oxidative stress markers in kidney tissues. AKBA and IA also remarkably decreased serum creatinine and blood urea nitrogen. These results suggest that AKBA and IA have protective effects against AKI in rats through regulating inflammation and oxidative stress.

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乙酰基-11-酮-β-乳香酸和醋酸茵陈通过抑制炎症和氧化应激减轻脂多糖诱发的急性肾损伤

在传统医学中，乳香一直被用于治疗各种炎症性疾病。乙酰基-11-酮-β-乳香酸（AKBA）和醋酸茵陈（IA）是乳香的两种活性成分，具有抗炎和抗氧化活性。本研究旨在探讨 AKBA 和 IA 对脂多糖（LPS）诱导的大鼠急性肾损伤（AKI）的保护作用。大鼠腹腔注射 AKBA 或 IA 2 周。30 分钟后，注射 LPS 诱导 AKI。收集血液样本和肾脏组织用于生化检测。AKBA和IA不仅能显著降低作为肾脏炎症标志物的白细胞介素-6，还能减轻肾组织中的氧化应激标志物。AKBA 和 IA 还能明显降低血清肌酐和血尿素氮。这些结果表明，AKBA 和 IA 通过调节炎症和氧化应激对大鼠的 AKI 具有保护作用。

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来源期刊

Saudi Journal of Kidney Diseases and Transplantation UROLOGY & NEPHROLOGY-

CiteScore

1.00

自引率

0.00%

发文量

审稿时长

53 weeks

期刊介绍： Saudi Journal of Kidney Diseases and Transplantation (SJKDT, ISSN 1319-2442) is the official publication of the Saudi Center for Organ Transplantation, Riyadh, Saudi Arabia. It is published six times a year. SJKDT publishes peer-reviewed original research work and review papers related to kidney diseases, urinary tract, renal replacement therapies, and transplantation. The journal publishes original papers and reviews on cell therapy and islet transplantation, clinical transplantation, experimental transplantation, immunobiology and genomics and xenotransplantation related to the kidney. The journal also publishes short communications, case studies, letters to the editors, an annotated bibliography and a column on news and views.