Evaluation of rapid antiretroviral initiation strategy in a cohort of newly diagnosed people living with HIV in Panama, 2018-2019.

IF 1.2 4区 医学 Q4 HEALTH POLICY & SERVICES Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2024-11-01 Epub Date: 2024-07-11 DOI:10.1080/09540121.2024.2373397
Juan Pablo Alvis-Estrada, Andrés Azmitia-Rugg, Ximena Sobalvarro-Stolz, Daniela Romo-Dueñas, Félix Díaz, Alexander Martínez, Rosa Elena Morales, Lissette Raquel Chang, Natalia Vega, Ana Belén Araúz, Gustavo Ávila-Montes
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Abstract

Antiretroviral therapy (ART) has been adopted as a form of HIV treatment and prevention. This study assesses rapid ART initiation using clinical outcomes such as viral load (VL) and CD4+ T lymphocytes count. Over the course of one year, the progress of newly diagnosed people living with HIV who started ART early in a hospital in Panama City was followed. The evaluation of early initiation of ART in achieving viral suppression (VL <200 copies/ml) was analyzed using descriptive statistics. Additionally, the cost difference between early (first 7 days) and late initiation of ART was evaluated from the perspective of the service provider. In total, 209 people were followed up during the study; 85% were male, 70% started ART on same day from hospital arrival, 80% had suppressed viral load at 6 months, and the median count of CD4 increased from 285 (IQR: 166-429) to 509 (IQR: 373-696) over 12 months. Starting ART early led to a 42% increase for the provider in terms of staffing costs; however, the clients had the opportunity to decrease absenteeism in daily activities. The results reveal that early initiation of ART generates clinical and economic benefits for the person in treatment.

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2018-2019年在巴拿马新诊断的艾滋病病毒感染者队列中对快速抗逆转录病毒启动策略的评估。
抗逆转录病毒疗法(ART)已成为艾滋病治疗和预防的一种方式。这项研究利用病毒载量(VL)和 CD4+ T 淋巴细胞计数等临床结果对快速启动抗逆转录病毒疗法进行了评估。在一年的时间里,我们对巴拿马城一家医院新确诊的艾滋病病毒感染者中早期开始抗逆转录病毒疗法者的病情进展进行了跟踪调查。评估早期开始抗逆转录病毒疗法对实现病毒抑制(VL
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3.50
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172
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