Investigating the Variability among Indicators for Quantifying Antimicrobial Use in the Intensive Care Units: Analysis of Real-world Evidence.

IF 1.5 Q3 CRITICAL CARE MEDICINE Indian Journal of Critical Care Medicine Pub Date : 2024-07-01 DOI:10.5005/jp-journals-10071-24745

Prity R Deshwal, Pramil Tiwari

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Abstract

This study investigated variability among four indicators for quantifying antimicrobial use in intensive care units (ICUs): defined daily doses (DDD), prescribed daily doses (PDD), duration of therapy (DOT), and length of therapy (LOT) and recommended the most clinically relevant approach. Retrospective data from patients who had received at least one antimicrobial was analyzed. Patients whose records were incomplete or expired were excluded. Duration of therapy (24433/1000 PDs) and LOTs (12832/1000 PDs) underestimated the overall consumption of antimicrobials compared with DDD of 28391/1000 PDs. Whereas PDD (46699/1000 PDs) overestimated it. Comparison analysis detected % differences of 13.94, 23.92, and 54.80% between DDD and DOT, DDD and PDD, and DDD and LOT, indicators respectively. Linear regression revealed stronger (r ² = 0.86), moderate (r ² = 0.50), and moderate (r ² =0.60) correlation between DDD and DOT, DDD and PDD and DDD and LOT indicators respectively. According to findings, combining DOT and DDD is a more practical method to quantify antimicrobial consumption in hospital ICUs.

How to cite this article: Deshwal PR, Tiwari P. Investigating the Variability among Indicators for Quantifying Antimicrobial Use in the Intensive Care Units: Analysis of Real-world Evidence. Indian J Crit Care Med 2024;28(7):662-676.

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调查重症监护病房抗菌药物使用量化指标之间的可变性：真实世界证据分析。

这项研究调查了用于量化重症监护病房（ICU）抗菌药物使用情况的四项指标之间的差异：规定日剂量（DDD）、处方日剂量（PDD）、疗程（DOT）和疗程长度（LOT），并推荐了与临床最相关的方法。对至少接受过一种抗菌药物治疗的患者的回顾性数据进行了分析。记录不完整或过期的患者被排除在外。与 28391/1000 PDs 的 DDD 相比，治疗持续时间（24433/1000 PDs）和 LOT（12832/1000 PDs）低估了抗菌药物的总体消耗量。而 PDD（46699/1000 PDs）则高估了这一数字。对比分析发现，DDD 和 DOT、DDD 和 PDD 以及 DDD 和 LOT 指标之间的差异率分别为 13.94%、23.92% 和 54.80%。线性回归显示，DDD 与 DOT、DDD 与 PDD 和 DDD 与 LOT 指标之间分别存在较强（r 2 = 0.86）、中等（r 2 = 0.50）和中等（r 2 = 0.60）的相关性。研究结果表明，结合 DOT 和 DDD 是量化医院重症监护室抗菌药物消耗量的一种更实用的方法：Deshwal PR, Tiwari P. Investigating the Variability among Indicators for Quantifying Antimicrobial Use in the Intensive Care Units：真实世界证据分析》。Indian J Crit Care Med 2024;28(7):662-676.

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来源期刊

Indian Journal of Critical Care Medicine CRITICAL CARE MEDICINE-

CiteScore

3.50

自引率

10.00%

发文量

299

期刊介绍： Indian Journal of Critical Care Medicine (ISSN 0972-5229) is specialty periodical published under the auspices of Indian Society of Critical Care Medicine. Journal encourages research, education and dissemination of knowledge in the fields of critical and emergency medicine.