A novel [4 + 3] annulation between isatin N,N’-cyclic azomethine 1,3-dipole and in situ generated nitrosoalkene for direct preparation of seven-membered heterocyclic spirooxindoles
Xia Li , Wen-Sheng Li , Xiao Fu , Wen-Juan Wan , Li-Xin Wang
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引用次数: 0
Abstract
A new [4 + 3] annulation between isatin N,N′–cyclic azomethine 1,3-dipole and nitrosoalkenes in situ generated from α-haloketone oximes has been disclosed. This new protocol is tolerable for a series of substrates and a novel series of seven-membered spiro oxindoles containing oxygen and nitrogen atoms were obtained in moderate to good yields (up to 83 %) under mild conditions.
期刊介绍：
Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.
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