The relationship between gender and pharmacology

Q2 Agricultural and Biological Sciences Current Research in Pharmacology and Drug Discovery Pub Date : 2024-01-01 DOI:10.1016/j.crphar.2024.100192
Samer Younes
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Abstract

The part of sexuality in pharmacology research was not acknowledged, and it was not thought-out to be a determinant that could impact strength and disease. For decades research has mainly contained male, women and animals, leading to a lack of news about syndromes in females. Still, it is critical to guarantee equal likeness so that determine the security, influence, and resistance of healing agents for all individuals. The underrepresentation of female models in preclinical studies over various decades has surpassed to disparities in the understanding, disease, and treatment of ailments 'tween genders. The closeness of sexuality bias has happened recognized as a contributing determinant to the restricted interpretation and replicability of preclinical research. Many demands operation have stressed the significance of including sexuality as a organic changeable, and this view is acquire growing support. Regardless of important progress in incorporating more female models into preclinical studies, differences prevail contemporary. The current review focuses on the part of sexuality and common in biomedical research and, therefore, their potential function in pharmacology and analyze the potential risks guide.

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性别与药理学的关系
性在药理学研究中的作用没有得到承认,也没有被认为是影响体力和疾病的决定因素。几十年来,研究对象主要是男性、女性和动物,因此缺乏关于女性综合征的新闻。尽管如此,保证平等的相似性至关重要,这样才能确定所有个体的安全性、影响力和对治疗剂的抵抗力。几十年来,临床前研究中女性模型的代表性不足,导致了两性在疾病的理解、疾病和治疗方面的差异。人们已经认识到,性别偏见是导致临床前研究的解释和可复制性受到限制的一个决定性因素。许多需求操作都强调了将性行为作为有机可变因素的重要性,这一观点正获得越来越多的支持。尽管在将更多女性模型纳入临床前研究方面取得了重要进展,但目前仍存在差异。目前的综述重点关注生物医学研究中性与共性的部分,因此,它们在药理学中的潜在功能,并分析潜在的风险指南。
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来源期刊
Current Research in Pharmacology and Drug Discovery
Current Research in Pharmacology and Drug Discovery Agricultural and Biological Sciences-Animal Science and Zoology
CiteScore
6.40
自引率
0.00%
发文量
65
审稿时长
40 days
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