Association between brominated flame retardants (PBDEs and PBB153) exposure and hypertension in U.S. adults: results from NHANES 2005-2016.

IF 5.3 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Environmental Health Pub Date : 2024-07-13 DOI:10.1186/s12940-024-01103-0
Dian Cheng, Zijun Chen, Jian Zhou, Yue Cao, Xin Xie, Yizhang Wu, Xiaorong Li, Xuecheng Wang, Jinbo Yu, Bing Yang
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Abstract

Background: Brominated Flame Retardants (BFRs) have attracted widespread concern due to their environmental persistence and potential toxicity. This study aims to examine the association between BFRs exposure and hypertension.

Methods: We used data from the National Health and Nutrition Examination Survey (NHANES) spanning 2005 to 2016 for the cross-sectional analysis. To evaluate the individual and combined impacts of BFRs exposure on hypertension, we utilized multivariate models, including generalized additive models, weighted quantile sum (WQS) regression, and Bayesian kernel machine regression (BKMR) models.

Results: 9882 individuals (48% male) aged ≥ 20 were included in the final analysis, of whom 4114 had hypertension. After controlling for potential covariates, higher serum concentrations of PBDE100 (OR: 1.26; 95% CI: 1.01, 1.57) and PBDE153 (OR: 1.50; 95% CI: 1.18, 1.88) were significantly associated with hypertension. A nonlinear relationship between PBDE28 and hypertension was observed (P = 0.03). Moreover, BFRs mixture were positively associated with the prevalence of hypertension in both the WQS (β:1.09; 95% CI: 1.02, 1.17; P = 0.02) and BKMR models.

Conclusion: Our study suggested that BFRs exposure is positively associated with hypertension in the general population. To confirm this association and elucidate the mechanisms, further research is required.

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美国成年人溴化阻燃剂(多溴联苯醚和多溴联苯153)暴露与高血压之间的关系:NHANES 2005-2016 年的结果。
背景:溴化阻燃剂(BFRs)因其在环境中的持久性和潜在毒性而受到广泛关注。本研究旨在探讨溴化阻燃剂暴露与高血压之间的关系:我们使用 2005 年至 2016 年的美国国家健康与营养调查(NHANES)数据进行横断面分析。为了评估溴化阻燃剂暴露对高血压的个体和综合影响,我们采用了多变量模型,包括广义加法模型、加权量子和(WQS)回归和贝叶斯核机器回归(BKMR)模型:最终分析共纳入 9882 名年龄≥ 20 岁的个体(48% 为男性),其中 4114 人患有高血压。在控制了潜在的协变量后,血清中 PBDE100(OR:1.26;95% CI:1.01,1.57)和 PBDE153(OR:1.50;95% CI:1.18,1.88)浓度较高与高血压显著相关。PBDE28 与高血压之间存在非线性关系(P = 0.03)。此外,在 WQS(β:1.09;95% CI:1.02,1.17;P = 0.02)和 BKMR 模型中,溴化阻燃剂混合物与高血压发病率呈正相关:我们的研究表明,在普通人群中,溴化阻燃剂暴露与高血压呈正相关。结论:我们的研究表明,在普通人群中,溴化阻燃剂暴露与高血压呈正相关。要证实这种关联并阐明其机制,还需要进一步的研究。
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来源期刊
Environmental Health
Environmental Health 环境科学-公共卫生、环境卫生与职业卫生
CiteScore
10.10
自引率
1.70%
发文量
115
审稿时长
3.0 months
期刊介绍: Environmental Health publishes manuscripts on all aspects of environmental and occupational medicine and related studies in toxicology and epidemiology. Environmental Health is aimed at scientists and practitioners in all areas of environmental science where human health and well-being are involved, either directly or indirectly. Environmental Health is a public health journal serving the public health community and scientists working on matters of public health interest and importance pertaining to the environment.
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