The role of exosomes derived from stem cells in nerve regeneration: A contribution to neurological repair

IF 4.6 2区 医学 Q1 NEUROSCIENCES Experimental Neurology Pub Date : 2024-07-14 DOI:10.1016/j.expneurol.2024.114882
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Abstract

Stem cell-derived exosomes have gained attention in regenerative medicine for their role in encouraging nerve regeneration and potential use in treating neurological diseases. These nanosized extracellular vesicles act as carriers of bioactive molecules, facilitating intercellular communication and enhancing the regenerative process in neural tissues. This comprehensive study explores the methods by which exosomes produced from various stem cells contribute to nerve healing, with a particular emphasis on their role in angiogenesis, inflammation, and cellular signaling pathways. By examining cutting-edge developments and exploring the potential of exosomes in delivering disease-specific miRNAs and proteins, we highlight their versatility in tailoring personalized therapeutic strategies. The findings presented here highlight the potential of stem cell-produced exosomes for use in neurological diseases therapy, establishing the door for future research into exosome-based neurotherapies.

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干细胞外泌体在神经再生中的作用:对神经修复的贡献
干细胞衍生的外泌体在促进神经再生和治疗神经系统疾病的潜在用途方面发挥着重要作用,因而在再生医学领域备受关注。这些纳米级细胞外囊泡是生物活性分子的载体,可促进细胞间的交流并增强神经组织的再生过程。本综合研究探讨了各种干细胞产生的外泌体促进神经愈合的方法,特别强调了它们在血管生成、炎症和细胞信号通路中的作用。通过研究前沿发展和探索外泌体在传递疾病特异性miRNA和蛋白质方面的潜力,我们强调了外泌体在定制个性化治疗策略方面的多功能性。本文的研究结果凸显了干细胞产生的外泌体用于神经系统疾病治疗的潜力,为未来基于外泌体的神经疗法研究打开了大门。
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来源期刊
Experimental Neurology
Experimental Neurology 医学-神经科学
CiteScore
10.10
自引率
3.80%
发文量
258
审稿时长
42 days
期刊介绍: Experimental Neurology, a Journal of Neuroscience Research, publishes original research in neuroscience with a particular emphasis on novel findings in neural development, regeneration, plasticity and transplantation. The journal has focused on research concerning basic mechanisms underlying neurological disorders.
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