{"title":"The influence of lifestyle factors on serum etonogestrel concentrations among contraceptive implant users","authors":"Aaron Lazorwitz , Jeanelle Sheeder , Stephanie Teal","doi":"10.1016/j.contraception.2024.110539","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div><span>To evaluate how diet, exercise, and substance use influence serum etonogestrel concentrations among </span>contraceptive implant users.</div></div><div><h3>Study design</h3><div>We conducted a cross-sectional analysis of healthy, reproductive-age etonogestrel<span> implant users. We assessed participants’ current diet, exercise, and substance (alcohol, tobacco, marijuana) use habits while simultaneously measuring serum etonogestrel concentrations. We used linear modeling to test for associations between survey responses and etonogestrel concentrations.</span></div></div><div><h3>Results</h3><div>Among 115 participants, exercise habits and substance use had no significant associations with etonogestrel concentrations, while increased caloric intake demonstrated inconsistent associations.</div></div><div><h3>Conclusion</h3><div>The lifestyle factors of diet, exercise, and substance use do not influence steady-state pharmacokinetics<span> among contraceptive implant users.</span></div></div><div><h3>Clinical trial registration</h3><div><span><span>Clinicaltrials.gov</span><svg><path></path></svg></span>, NCT03092037.</div></div>","PeriodicalId":10762,"journal":{"name":"Contraception","volume":"140 ","pages":"Article 110539"},"PeriodicalIF":2.5000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Contraception","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0010782424002282","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/11 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Objective
To evaluate how diet, exercise, and substance use influence serum etonogestrel concentrations among contraceptive implant users.
Study design
We conducted a cross-sectional analysis of healthy, reproductive-age etonogestrel implant users. We assessed participants’ current diet, exercise, and substance (alcohol, tobacco, marijuana) use habits while simultaneously measuring serum etonogestrel concentrations. We used linear modeling to test for associations between survey responses and etonogestrel concentrations.
Results
Among 115 participants, exercise habits and substance use had no significant associations with etonogestrel concentrations, while increased caloric intake demonstrated inconsistent associations.
Conclusion
The lifestyle factors of diet, exercise, and substance use do not influence steady-state pharmacokinetics among contraceptive implant users.
期刊介绍：
Contraception has an open access mirror journal Contraception: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review.
The journal Contraception wishes to advance reproductive health through the rapid publication of the best and most interesting new scholarship regarding contraception and related fields such as abortion. The journal welcomes manuscripts from investigators working in the laboratory, clinical and social sciences, as well as public health and health professions education.
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